Usage of U7 small nuclear ribonucleic acid in gene therapy of hemoglobin D Punjab disorder: Rationale?

Indian Journal of Human Genetics
Viroj Wiwanitkit

Abstract

Hemoglobin (Hb) D Punjab disorder is a congenital hemoglobinopathy described in India. It is a disorder due to defect in beta-globin gene. Here, the author assesses the possibility of U7.623 gene therapy for Hb D Punjab disorder. A standard bioinformatic analysis to study the effect of co-expression between nucleic acid sequence for human Hb D Punjab beta-globin chain and U7.623 was performed. It can be seen that fully recovery of Hb function and biological process can be derived via gene ontology study. Here, there is a rationale to use U7 small nuclear ribonucleic acid as a possible tool for gene therapy in Hb D Punjab disorder.

References

Mar 25, 1991·Nucleic Acids Research·S C Phillips, P C Turner
Jan 1, 1986·Hemoglobin·Y T ZengC Y Chen
Jan 1, 1970·Acta Haematologica·S Ozsoylu
Feb 19, 1999·Gene·I GerinE Van Schaftingen
Dec 12, 2003·Bioinformatics·Salim KhanCarl J Schmidt

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