[Use (and abuse) of antibiotics in perinatal medicine].

Anales de pediatría : publicación oficial de la Asociación Española de Pediatría (A.E.P.)
Marcelo CardettiAugusto Sola

Abstract

The rational use of antibiotics (ATB) implies that patients receive those adequate for their clinical needs, in correct doses according to their individual conditions, during an adequate period of time, and at the lowest cost for them and their community. The highest rate of ATB abuse occurs during the perinatal period, despite the fact that there is evidence of multiple short- and long-term negative effects. Furthermore, this abuse is associated with increased costs of medical care. To update and report the evidence on the use, abuse, and adverse effects of ATB in perinatal medicine, and possible measures to prevent them, and thus improve health care outcomes and costs. A review and analysis was performed from the literature related to the use of ATB in perinatal medicine up to February 2020. ATB abuse in perinatal medicine ranges from 50% to 70%, with even higher rates in some neonatal centres. Adverse effects include death, increased microbial resistance, along with microbiome abnormalities and dysbiosis that lead to serious life-long complications such as infections, allergies, autoimmune disorders, gastrointestinal disorders, arthritis, asthma, obesity, and perhaps cancer. Preventing and reducing the abuse of ATB would lea...Continue Reading

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Citations

Aug 17, 2021·AMB Express·Lulu YangGuven Ozdemir

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