Use and Outcomes Associated With Perioperative Amiodarone in Cardiac Surgery

Journal of the American Heart Association
Auras AtreyaPeter K Lindenauer

Abstract

Background In randomized controlled trials, perioperative administration of amiodarone has been shown to reduce the incidence of postoperative atrial arrhythmias and length of stay (LOS) among patients undergoing coronary bypass surgery. However, little is known about the use or effectiveness of perioperative amiodarone in routine clinical practice. Methods and Results We studied patients ≥18 years old without a previous history of atrial or ventricular arrhythmias who underwent elective coronary bypass surgery between 2013 and 2014 within a network of 235 US hospitals. Perioperative amiodarone was defined as receipt of amiodarone either on the day of or the day preceding surgery. We used covariate-adjusted modeling and instrumental variable methods to examine the association between receipt of amiodarone and the development of atrial arrhythmias, in-hospital mortality, readmission, LOS, and cost. Of 12 758 patients, 2195 (17.2%) received perioperative amiodarone, 3330 (26.1%) developed atrial arrhythmias postoperatively, and the average LOS was 6.4 days (±2.6 days). Instrumental variable analysis showed that receipt of perioperative amiodarone was associated with lower risk of atrial arrhythmias (risk difference -11 percentage...Continue Reading

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Citations

Dec 3, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Eric T FeduskaJordan E Goldhammer
Sep 3, 2021·Seminars in Cardiothoracic and Vascular Anesthesia·Jose Liza ReshmiAveek Jayant

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Methods Mentioned

BETA
coronary artery bypass

Software Mentioned

STATA
Statistical Analysis System

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