PMID: 6970493Oct 1, 1980Paper

Use-dependent conduction block produced by volatile general anesthetic agents

Acta Anaesthesiologica Scandinavica
G Strichartz

Abstract

The ability of tertiary amine local anesthetic, barbiturates, and several volatile general anesthetics to block conduction of the compound action potential was measured in the frog sciatic nerve. Action potentials from large myelinated fibers were monitored using a desheathed nerve preparation in a sucrose-gap chamber. Supramaximal stimuli were applied over a range of stimulus frequencies from 0.1 Hz to 500 Hz. All three anesthetic agents produced a phasic, frequency-dependent anesthetic block, which developed with repetitive stimulation and returned to a tonic level when the nerve remained a rest. Saxitoxin produced a frequency-independent block. The frequency-dependent conduction block produced by the teritary amine anesthetic and by the barbiturates were potentiated by elevated Ca2+ in the solution bathing the nerve, but Ca2+ changes did not modify the block produced by any of the volatile anesthetics, so the latter agents probably act by a different mechanism than local anesthetics or barbiturates.

References

Aug 1, 1978·Biophysical Journal·L Y HuangW A Catterall
Jul 1, 1973·The Journal of General Physiology·G R Strichartz
Aug 1, 1973·Toxicon : Official Journal of the International Society on Toxinology·P N StrongJ F Keana
Feb 1, 1968·The Journal of General Physiology·B Hille
Jul 1, 1962·The Journal of General Physiology·F J JULIAND E GOLDMAN

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Citations

Nov 19, 1985·European Journal of Pharmacology·C PostC G Persson
May 14, 1998·Anesthesiology·L Ratnakumari, H C Hemmings
Aug 1, 1981·Journal of Dental Research·G R Strichartz

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