PMID: 11915065Mar 27, 2002Paper

Use of a charged lidocaine derivative, tonicaine, for prolonged infiltration anesthesia

Regional Anesthesia and Pain Medicine
Mohammed A KhanGing Kuo Wang

Abstract

We tested the hypothesis that the duration of cutaneous anesthesia elicited by the permanently charged compound N-phenylethyl lidocaine (tonicaine) would be longer than that elicited by its parent structure, lidocaine, and that it would be less affected by epinephrine (epi), after subcutaneous injection in rats, as a model for infiltration anesthesia. Subcutaneous injections were performed on the shaved dorsal skin of rats with either tonicaine or lidocaine (0.1% or 0.5%, n = 8 in each group) with and without epi (1:200,000). Inhibition of the cutaneous trunci muscle reflex was quantitatively evaluated by a blinded observer by the number of times pinpricks failed to elicit the nocifensive motor response out of a total of 6 pinpricks applied to the injected area. Duration of complete nociceptive blockade in the 0.5% tonicaine and lidocaine groups was 619 +/- 47 and 58 +/- 2 minutes, respectively; duration of full recovery in these groups was 1,106 +/- 19 and 86 +/- 3 minutes, respectively. Epi increased the duration of complete block in the 0.5% tonicaine and lidocaine groups to 750 +/- 13 and 97 +/- 11 minutes, respectively, and the duration of full recovery to 1,185 +/- 13 and 172 +/- 6 minutes, respectively. Skin toxicity was...Continue Reading

References

Jul 1, 1989·Annals of Plastic Surgery·B G AycockS B Moody
Oct 1, 1986·The Journal of the American Dental Association·A L HasseN R Garrett
Jul 1, 1984·Anesthesia and Analgesia·A V Nadkarni, A S Tondare
Jun 1, 1982·Annals of Emergency Medicine·W BarkerR F Edlich

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Citations

May 3, 2008·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Chin C ChuJhi J Wang
Apr 14, 2010·Anaesthesia·M D Wiles, M H Nathanson
Sep 5, 2017·World Journal of Clinical Cases·Amlan SwainDevi Prasad Samaddar

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