Use of a clinical MR scanner for imaging the rat brain

Brain Research Bulletin
D A SmithG W Arendash

Abstract

Magnetic resonance imaging (MRI) and magnetic resonance spectroscopy are established techniques that enable noninvasive anatomic and functional tissue characterization in vivo. These tools have been employed to probe experimental models of neoplasia, cerebrovascular disease, brain injury, and neurotransplantation in small animals. To date, these studies have been executed primarily on research-dedicated instruments of limited availability or resolution. Using relatively straightforward software and hardware modifications of a widely used clinical MRI unit, we were able to image numerous structures within the living rat brain including the neostriatum, hippocampus, periaqueductal gray, and the ventricular system. Illustrative applications of this imaging technique in two intracerebral infusion models involving rats are presented. Such adaptation of clinical MRI scanners has the potential to significantly expand the availability of high resolution in vivo imaging of small animals for a variety of experimental protocols.

References

Jan 1, 1990·Journal of Cardiovascular Pharmacology·A Sauter, M Rudin
Jul 1, 1991·Stroke; a Journal of Cerebral Circulation·H LesiukJ Saunders
Jan 1, 1991·Investigative Radiology·U P SchmiedlJ A Nelson
Jun 1, 1991·Stroke; a Journal of Cerebral Circulation·R A KnightD Peck
Mar 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J MintorovitchP R Weinstein
Aug 1, 1989·Stroke; a Journal of Cerebral Circulation·R H BradleyG Hillman
Nov 1, 1988·Magnetic Resonance Imaging·M JungkeP Pfannenstiel
Mar 1, 1988·Radiology·V M RungeL S Adelman
Apr 1, 1987·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G A JohnsonB P Drayer

❮ Previous
Next ❯

Citations

Jan 1, 2009·Radiological Physics and Technology·Akihide YamamotoHidehiro Iida
Jul 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Elaine HolmesSarah J Tabrizi
Apr 20, 2000·Journal of Neuroscience Methods·R GuzmanH R Widmer
Dec 16, 2003·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Wouter R van FurthJames T Rutka
Sep 26, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Marie Poirier-QuinotLuc Darrasse
Oct 6, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Masashi YamanamiYasuhide Nakayama
Sep 19, 2014·Journal of Mathematical Biology·Ola Hössjer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.