Use of a functionalized introducer sheath and bioimpedance spectroscopy for real-time detection of vascular access complications

Journal of Medical Engineering & Technology
C Alexander ArevalosMehdi Razavi

Abstract

Internal bleeding complications (IBCs) occurring at vascular access sites are associated with worsening patient outcomes and increased costs. This study assessed the IBC detection capabilities of a bioimpedance spectroscopy (BS) monitoring system that uses a novel functionalized introducer sheath. The device was tested in three large animal models of a clinical IBC. A 120-mL perivascular saline injection after sheath insertion, a slow continuous perivascular saline injection of 2.6 mL min(-1) of saline and a vessel-puncture model were tested. In each case, a significant change in normalized impedance was detected compared to the controls. This study provides evidence that a functionalized vascular access sheath using BS can detect an intraprocedural vascular access IBC. Clinical use of the device could help guide patient care by directly detecting vascular access complications early, thereby preventing unnecessary diagnostic scans to rule out the presence of IBCs.

References

May 17, 2005·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Dimitri A SherevBruce N Brent
Jul 5, 2006·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Daniel BurkhoffHoward A Cohen
Apr 11, 2007·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Leonid YatskarJames Slater
Dec 17, 2010·Circulation·Véronique L RogerUNKNOWN American Heart Association Statistics Committee and Stroke Statistics Subcommittee
Aug 16, 2013·Physiological Measurement·Yasin MamatjanAndy Adler

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Citations

Aug 24, 2017·Journal of Cardiovascular Electrophysiology·David A BurklandMehdi Razavi
Apr 26, 2020·Pacing and Clinical Electrophysiology : PACE·Mathews JohnMehdi Razavi

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