PMID: 8946639Nov 1, 1996Paper

Use of a lactoferrin assay in the differential diagnosis of female genital tract infections and implications for the pathophysiology of bacterial vaginosis

Sexually Transmitted Diseases
M F ReinR L Guerrant

Abstract

Lactoferrin has served as a marker for leukocytes (polymorphonuclear neutrophils [PMN]) in clinical specimens. To investigate the potential of a lactoferrin latex agglutination test in the differential diagnosis of female genital infection. Lactoferrin was quantified in the vaginal discharge of women with genital infections. Polymorphonuclear neutrophils were added to vaginal discharge and observed over 8 hours. Vaginal lactoferrin titers were significantly elevated in women with trichomoniasis, candidiasis, and bacterial vaginosis (BV). Using a lactoferrin titer of > or = 1:40, the assay has a sensitivity of 79.3% and a specificity of 83.3% for the presence of trichomoniasis or bacterial vaginosis. Vaginal discharge from women with BV significantly destroyed added PMN. Vaginal lactoferrin determinations may provide a useful screen for inflammatory genital infections and identify individuals who require additional diagnostic evaluation. The observed absence of PMN in bacterial vaginosis may result from the destruction of PMN in vaginal discharge rather than the absence of a primary inflammatory response.

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Citations

Mar 7, 2007·Current HIV/AIDS Reports·Elizabeth St JohnGregory T Spear
Jun 1, 2002·Obstetrics and Gynecology·Lauren SteinhandlerCourtney Cruickshank
May 11, 2004·The Journal of Veterinary Medical Science·Po-Wen ChenFrank Chinhung Mao
Jul 12, 2016·BJOG : an International Journal of Obstetrics and Gynaecology·D NasioudisS S Witkin
Apr 10, 2008·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Natalia NikolaitchoukInger Mattsby-Baltzer
Jul 24, 2007·Indian Journal of Medical Microbiology·A AggarwalR Jain
Aug 2, 2019·Current Infectious Disease Reports·Iara M LinharesSteven S Witkin

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