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Use of a Lymphatic Drug Delivery System and Sonoporation to Target Malignant Metastatic Breast Cancer Cells Proliferating in the Marginal Sinuses

Scientific Reports

Sep 13, 2019

Shigeki KatoTetsuya Kodama

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Abstract

Lymph node (LN) metastasis through the lymphatic network is a major route for cancer dissemination. Tumor cells reach the marginal sinuses of LNs via afferent lymphatic vessels (LVs) and form metastatic lesions that lead to distant metastasis. Thus, targeting of metastatic cells in the ...read more

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Left Ventricular Hypertrophy
Breast Cancer Cell
Disseminated Malignant Neoplasm
Structure
Biological Neural Networks
Contrast Media
Doxorubicin
Lactobacillus phage Lv-1
Neoplastic Cell
Anatomical Space Structure
9
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Use of a Lymphatic Drug Delivery System and Sonoporation to Target Malignant Metastatic Breast Cancer Cells Proliferating in the Marginal Sinuses

Scientific Reports

Sep 13, 2019

Shigeki KatoTetsuya Kodama

PMID: 31519920

DOI: 10.1038/s41598-019-49386-5

Abstract

Lymph node (LN) metastasis through the lymphatic network is a major route for cancer dissemination. Tumor cells reach the marginal sinuses of LNs via afferent lymphatic vessels (LVs) and form metastatic lesions that lead to distant metastasis. Thus, targeting of metastatic cells in the ...read more

Mentioned in this Paper

Left Ventricular Hypertrophy
Breast Cancer Cell
Disseminated Malignant Neoplasm
Structure
Biological Neural Networks
9

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