Use of a Peltier chip with a newly devised local brain-cooling system for neocortical seizures in the rat. Technical note

Journal of Neurosurgery
Hirochika ImotoMichiyasu Suzuki

Abstract

Local cortical cooling for termination of epileptic discharges (EDs) has recently become a focus of research. The authors report on a newly devised cooling system that uses a thermoelectric (Peltier) chip and examine the system's performance in experimental neocortical seizures. Experiments were performed in adult male Sprague-Dawley rats after induction of halothane anesthesia. The Peltier chip was attached to a heat sink with a water channel. Two silicon tubes were connected to the heat sink, and water at 37 degrees C was circulated in the channel. The newly designed device was placed on the surface of the cortex. Kainic acid (KA) was injected into the cortex to provoke EDs. In the nonepileptic cortex, the temperature of the cortical surface decreased to 14.8 +/- 1.5 degrees C and that 2 mm below the surface to 27.1 +/- 3.1 degrees C within 30 seconds after the start of cooling. The temperature of the heated side of the chip was maintained at approximately 36.9 degrees C. Without water circulation, the temperature of the cortical surface decreased to 20 degrees C but soon began to increase, peaking at 30 degrees C. The temperature of the heated side of the chip rose to more than 60 degrees C. The EDs, which appeared within 20...Continue Reading

References

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Citations

Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Steven M Rothman
Feb 28, 2008·Nature Clinical Practice. Neurology·William C Stacey, Brian Litt
Oct 5, 2010·Neurologia Medico-chirurgica·Masami FujiiMichiyasu Suzuki
Mar 17, 2009·Journal of Neurosurgery·Takayuki OkuMichiyasu Suzuki
Apr 2, 2008·Journal of Neurosurgery·Nobuhiro TanakaMichiyasu Suzuki
Oct 2, 2008·Journal of Neurosurgery·Alexander V ShulyakovMarc R Del Bigio
Dec 29, 2009·Neuroscience Research·Hiroshi FujiokaMichiyasu Suzuki
Sep 26, 2009·Epilepsy & Behavior : E&B·Steven C SchachterUNKNOWN Summit Contributors
Jun 12, 2017·Experimental Neurology·Guoping RenXiaofeng Yang
Aug 18, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Sadahiro NomuraMichiyasu Suzuki
Mar 21, 2019·Neurologia Medico-chirurgica·Yeting HeMichiyasu Suzuki
Jul 1, 2011·Neurosurgery·Faisal A Al-OtaibiAndres M Lozano
Oct 5, 2020·Seizure : the Journal of the British Epilepsy Association·Bence CsernyusAnita Pongrácz

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