Use of a predictive protocol to measure the antimicrobial resistance risks associated with biocidal product usage

American Journal of Infection Control
Rebecca WesgateJean-Yves Maillard

Abstract

In this study we assessed the propensity of biocide exposure in the development of antimicrobial resistance in bacteria. Our protocol is based on reporting changes in established antimicrobial susceptibility profiles in biocides and antibiotics after during use exposure to a product. The during use exposure reflects worse conditions of product use during application. It differs from the term low concentration, which usually reflects a concentration below the minimal inhibitory concentration, but not necessarily a concentration that occurs in practice. Our results showed that exposure to triclosan (0.0004%) was associated with a high risk of developing resistance and cross-resistance in Staphylococcus aureus and Escherichia coli. This was not observed with exposure to chlorhexidine (0.00005%) or a hydrogen peroxide-based biocidal product (in during use conditions). Interestingly, exposure to a low concentration of hydrogen peroxide (0.001%) carried a risk of emerging resistance to antibiotics if the presence of the oxidizing agent was maintained. We observed a number of unstable clinical resistances to antibiotics after exposure to the cationic biocide and oxidizing agent, notably to tobramycin and ticarcillin-clavulanic acid. U...Continue Reading

References

Feb 5, 2000·The Journal of Hospital Infection·A D Russell
Mar 26, 2002·Science·UNKNOWN AAAS Committee on Scientific Freedom and Responsibility
Jan 5, 2008·Annual Review of Biochemistry·James A Imlay
Jul 8, 2008·The Journal of Hospital Infection·D J H MartinJ-Y Maillard
May 1, 2009·Journal of Clinical Microbiology·Rafael Silva DuarteJorge Luiz Mello Sampaio
Jun 17, 2009·Journal of Medical Microbiology·Yagang ChenLanjuan Li
Aug 12, 2009·Applied and Environmental Microbiology·Siyun WangWei Zhang
Jul 13, 2011·Antimicrobial Agents and Chemotherapy·Ellen G ChristensenVicky G Kastbjerg
Jun 19, 2013·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Jean-Yves MaillardJohn Threlfall
Oct 22, 2013·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Mary LenahanCatherine M Burgess
Dec 24, 2013·International Journal of Food Microbiology·Miguel Angel Fernández-FuentesAntonio Gálvez
Mar 19, 2014·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Gustaf PragBo Söderquist
Feb 1, 2015·Applied and Environmental Microbiology·Laura KnappJean-Yves Maillard
May 20, 2015·BMC Microbiology·Mette Rørbæk GantzhornLine Elnif Thomsen

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Citations

Jul 28, 2016·Science·Alyson L Yee, Jack A Gilbert
Sep 13, 2016·Journal of Infection and Public Health·Marianne FrieriAnthony Boutin
Aug 2, 2018·Journal of Applied Microbiology·O S Imade, F I Akinnibosun
Sep 20, 2018·International Journal of Environmental Health Research·Jasna HrenovicIvica Kisic
Mar 19, 2020·Journal of Medical Microbiology·Rebecca WesgateJean-Yves Maillard
Nov 17, 2016·Frontiers in Microbiology·Andrew C SingerAlwyn Hart
Jul 26, 2018·Frontiers in Physiology·Siavash AtashgahiWillem M de Vos
Jan 7, 2021·Biomacromolecules·Davide CalifanoKaren J Edler
May 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Robert Davies, Andrew Wales
Mar 7, 2021·International Journal of Molecular Sciences·Aleksandra Rapacka-ZdonczykMariusz Grinholc
Jan 21, 2021·Antimicrobial Agents and Chemotherapy·Tristan RossignolChristophe d'Enfert
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Imogen Anne Jones, Lovleen Tina Joshi
May 30, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·José Castellanos-RozoAntonio Gálvez
Jul 6, 2021·JAC-antimicrobial Resistance·Jean-Yves MaillardRose Cooper
Apr 21, 2018·Microbiology Spectrum·Jean-Yves Maillard
Oct 30, 2021·Frontiers in Microbiology·Ning TangFengxiu Ouyang

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