Use of a Si/CdTe Compton Camera for In vivo Real-Time Monitoring of Annihilation Gamma Rays Generated by Carbon Ion Beam Irradiation

Frontiers in Oncology
Shintaro ShibaTakashi Nakano

Abstract

The application of annihilation gamma-ray monitoring to the adaptive therapy of carbon ion radiotherapy (C-ion RT) requires identification of the peak intensity position and confirmation of activated elements with annihilation gamma-rays generated at the C-ion-irradiated site from those transported to unirradiated sites. Real-time monitoring of C-ion-induced annihilation gamma-rays was implemented using a Compton camera in a mouse model. An adult C57BL/6 mouse was anesthetized, and C-ion beams were directed into the abdomen at 1 × 109 particles/s for 20 s. The 511 keV annihilation gamma-rays, generated by the interaction between the irradiated C-ion beam and the target mouse, were detected using a silicon/cadmium telluride (Si/CdTe) Compton camera for 20 min immediately after irradiation. The irradiated site and the peak intensity position of 511 keV gamma emissions due to C-ion beam irradiation on a mouse were observed at the abdomen of the mouse by developing Compton images. Moreover, the positron emitter transport was observed by evaluating the range of gamma-ray emission after the C-ion beam irradiation on the mouse. Our data suggest that by confirming the peak intensity and beam range of C-ion RT with Si/CdTe-based Compton...Continue Reading

References

Apr 29, 1999·International Journal of Radiation Oncology, Biology, Physics·T KanaiK Kawachi
Dec 1, 2000·Physics in Medicine and Biology·K Parodi, W Enghardt
Apr 13, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Takashi NakanoHirohiko Tsujii
Nov 18, 2006·Physics in Medicine and Biology·Igor PshenichnovWalter Greiner
Sep 9, 2009·International Journal of Radiation Oncology, Biology, Physics·Masakazu ShimizuYoshio Hishikawa
Oct 31, 2012·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·J SorriauxE Sterpin
Apr 9, 2013·Physics in Medicine and Biology·Soo Mee KimJae Sung Lee
May 8, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Julia BauerKatia Parodi
Feb 2, 2015·The Lancet Oncology·Tadashi KamadaWilliam T Chu
Feb 9, 2016·Physics in Medicine and Biology·Hideaki TashimaTaiga Yamaya
Sep 30, 2016·Journal of Applied Clinical Medical Physics·Elsa Y León MarroquinOlivia A García-Garduño
Nov 22, 2016·International Journal of Radiation Oncology, Biology, Physics·Daisuke IrieTakashi Nakano
Jan 7, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Satoshi AbeTakashi Nakano
Dec 8, 2015·Biochemistry and Biophysics Reports·Masayuki MunekaneShuichi Enomoto
Oct 11, 2017·Physics in Medicine and Biology·M FontanaÉ Testa
Nov 5, 2017·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Makoto SakaiTakashi Nakano
Sep 18, 2018·Physics in Medicine and Biology·Makoto SakaiTakashi Nakano
Sep 21, 2018·Cancers·Tatsuya OhnoUNKNOWN Working Group for Gynecologic Cancer
Oct 28, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kei ShibuyaTakashi Nakano
Nov 30, 2018·Frontiers in Oncology·Junyu ZhangJingyi Cheng
Dec 12, 2018·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Makoto SakaiTakashi Nakano
Jan 23, 2019·Physics in Medicine and Biology·Raj Kumar ParajuliTakashi Nakano
Jul 20, 2019·Physics in Medicine and Biology·Takashi NakanoTadayuki Takahashi
Sep 11, 2019·Scientific Reports·Makoto SakaiTakashi Nakano
Jan 10, 2020·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·A BongrandG Montarou

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Citations

Nov 6, 2021·Scientific Reports·Raj Kumar ParajuliMutsumi Tashiro

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Methods Mentioned

BETA
gamma-ray

Software Mentioned

OpenPET

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