Use of a symptom-based questionnaire to screen for the presence of significant voiding dysfunction in patients with multiple sclerosis and lower urinary tract symptoms: a pilot study.

Journal of Neurology
Vivien LiJeremy Chataway

Abstract

Lower urinary tract dysfunction is common in people with multiple sclerosis, leading to overactive bladder symptoms, voiding difficulties or a combination. First-line medications for overactive bladder symptoms are effective. Current guidelines recommend measuring post-void residual volume (PVR) before commencing these treatments, as they can potentially exacerbate voiding difficulties in those with significant underlying voiding dysfunction (pre-treatment PVR > 100 ml). However, facilities to do so are not readily available to all clinicians, potentially delaying effective therapy. To conduct a pilot study investigating the association between lower urinary tract symptoms and PVR volume in people with multiple sclerosis using a validated questionnaire and to determine if questionnaire scores can be used to exclude a significantly elevated (> 100 ml) PVR volume. Patients with multiple sclerosis referred to a tertiary hospital uro-neurology service completed the Urinary Symptom Profile questionnaire and underwent PVR measurement by bladder ultrasound. A ratio of the questionnaire low stream score/total score was calculated to standardise the relative degree of voiding symptoms compared to overall lower urinary tract symptoms. Of...Continue Reading

References

Mar 1, 1993·Journal of Neurology, Neurosurgery, and Psychiatry·C D BettsC J Fowler
Dec 4, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·C J Fowler, K J O'Malley
Nov 16, 2004·The Journal of Urology·Mark MillemanMichael L Guralnick
Jan 15, 2013·Handbook of Clinical Neurology·Jalesh N PanickerClare J Fowler
Mar 17, 2015·Lancet Neurology·Daniel OntanedaJeremy Chataway
Jan 27, 2016·Journal of the Neurological Sciences·Amit BatlaJalesh N Panicker
Sep 28, 2017·Orphanet Journal of Rare Diseases·Meher LadPaola Giunti
Apr 4, 2018·International Neurourology Journal·Camille ChesnelUNKNOWN GRAPPPA (Groupe de Recherche Appliquée à la Pelvi-Périnéologie de la Personne Agée)
Jul 12, 2018·International Neurourology Journal·Damien MotavasseliGérard Amarenco

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