Abstract
A biodegradable cyanoacrylate glue was tested for its ability to close bladder injuries in an established porcine model. Inflammation and encrustation associated with this glue were examined in a rabbit model. Four domestic pigs underwent transverse cystotomy, which was closed with absorbable cyanoacrylate glue. Four weeks later the bladder was distended with normal saline to evaluate the repair. A total of 45 rabbits underwent cystotomy, which was closed with polyglactin suture, absorbable cyanoacrylate glue or nonabsorbable 2-octyl cyanoacrylate glue. The bladder was harvested at 4 or 12 weeks to evaluate inflammation, microcalcification and encrustation. All 4 pig bladders tolerated a pressure of 200 mm. Hg 4 weeks after closure. In the rabbit bladders there was no difference in inflammation in the groups at 4 and 12 weeks. The absorbable glue and suture groups had less microcalcification than the 2-octyl cyanoacrylate glue group at 4 and 12 weeks (p = 0.01 and 0.02, respectively). Encrustation was less in the suture and absorbable glue groups than in the 2-octyl cyanoacrylate glue group at 4 and 12 weeks (p = 0.004 and 0.02, respectively). An experimental absorbable cyanoacrylate glue has the strength to seal a large cystot...Continue Reading
References
Jun 1, 1992·British Journal of Urology·S A HolmesH N Whitfield
Oct 1, 1991·Urology·A K LevinsonB Lichtiger
Feb 1, 1990·The Journal of Surgical Research·R Lerner, N S Binur
Mar 1, 1989·Urology·H B KramW C Shoemaker
Jan 1, 1968·Annals of the New York Academy of Sciences·C W Cooper, R D Falb
May 1, 1966·Journal of Neurosurgery·J Dutton, P O Yates
Apr 1, 1993·Journal of Biomaterials Applications·D H Sierra
May 21, 1997·JAMA : the Journal of the American Medical Association·J QuinnP Johns
Oct 6, 1997·British Journal of Urology·C G EdenR K Carruthers
Jul 16, 1999·Journal of Endourology·R BeduschiJ S Wolf
Apr 5, 2000·The Journal of Laryngology and Otology·R M AdamsonF Stafford
May 8, 2000·The Journal of Urology·J S WolfJ E Montie
Nov 25, 2000·British Journal of Plastic Surgery·M Vossen, J J Hage
Apr 18, 2001·Urology·R MarcovichJ S Wolf
Citations
Nov 16, 2007·Urological Research·Murat KosanMesut Cetinkaya
Jan 14, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jiri ParalMartin Vejbera
Mar 27, 2004·Gastrointestinal Endoscopy·Gregory B Haber
Dec 6, 2006·Journal of Endourology·Luca CarmignaniFrancesco Rocco
Mar 5, 2008·Journal of Endourology·James F BorinRalph V Clayman
May 29, 2003·The Journal of Urology·Mario SoferHaim Matzkin