PMID: 38571Jul 1, 1979

Use of aerosils in activating plasma prekallikrein

Voprosy medit︠s︡inskoĭ khimii
K N Veremeenko, N F Pogorelaia

Abstract

Activation of prekallikreine from human blood plasma was studied using silica (airsiles), which carried functional groups with acidic and alkaline properties on the surface. Prekallikrein was similarly activated by amino- and carboxyairsiles, possessing positive and negative electric charges, respectively, at neutral pH value in a medium. Lysozyme, ribonuclease and spermidine inhibited partially the prekallikreine activation; spermine inhibited it completely.

Related Concepts

Enzyme Activation
Hydrogen-Ion Concentration
Padutin
Plasma Prokallikrein A
Quso G-32
Surface Properties

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