Use of afterload hemodynamic stress as a practical method for assessing cardiac performance in rats with heart failure

Canadian Journal of Physiology and Pharmacology
L dos SantosPaulo J F Tucci

Abstract

After myocardial infarction, the hemodynamics under basal conditions might appear to be unaltered, which makes it difficult to identify cardiac dysfunction by the usual approaches. Thus, we tested the response to sudden afterload stress in infarcted rats with apparently normal ejection function. Control (CT) and infarcted (MI) Wistar rats with various MI sizes were submitted to echocardiography 30 days after coronary occlusion, followed by assessment of hemodynamics under basal conditions and during a pharmacologically induced sudden pressure overload (phenylephrine 15-25 microg/kg, i.v.). Coronary occlusion resulted in cardiac remodeling proportional to MI size, although several functional parameters such as systolic pressure (SP), stroke volume (SV), and stroke work (SW) of all MI rats were similar to those of CT rats. However, the afterload stress that was produced led to a relative preservation of SV and an increase of SW in CT rats; MI rats exhibited a significant reduction in SV and SW generation, although global cardiac function was normal under basal conditions, as indicated by regular echocardiography and hemodynamics assessment. Thus, we propose the use of sudden pharmacologically induced afterload stress as a practic...Continue Reading

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Citations

Aug 1, 2015·Journal of Molecular and Cellular Cardiology·Gisele K CoutoLuciana V Rossoni
Jul 16, 2013·International Journal of Cardiology·Leonardo dos SantosPaulo J F Tucci
Aug 11, 2011·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J G MillM P Baldo
Apr 20, 2020·Stem Cell Reviews and Reports·Stella Souza VieiraAndrey Jorge Serra
Jan 30, 2015·Molecular and Cellular Biochemistry·Luiz Henrique Soares de AndradeAlessandra Medeiros
Dec 11, 2020·BioMed Research International·Danilo Sales BocaliniLeonardo Dos Santos

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