Use of alternative receptors different than alpha-dystroglycan by selected isolates of lymphocytic choriomeningitis virus

Virology
Stefan KunzMichael B A Oldstone

Abstract

Long-term infections with viruses permit the generation of variants that evolve specific growth advantages in certain tissues and may show altered disease potentials. The selection of such variants is influenced by the host tissue and often involves virus-receptor interactions. Here we report studies of receptor usage by several lymphocytic choriomeningitis virus (LCMV) isolates that expressed different disease patterns. Consistent with our previous studies, we found that, with one exception, multiple LCMV variants that cause suppression of immune responses bound with high affinity to their cellular receptor alpha-dystroglycan (alpha-DG) and were dependent on alpha-DG for entry and infection. The exception also bound strongly to alpha-DG but was not dependent on alpha-DG for entry and infection. In contrast, those variants of LCMV that do not suppress the immune response either displayed low or no binding affinity for alpha-DG and used alternative receptors in addition to or instead of alpha-DG for entry and infection. For all alpha-DG binding variants, alpha-DG represents the preferred receptor in DG-expressing cells, as soluble alpha-DG blocked their infection of DG-deficient cells, indicating that binding of alpha-DG to the ...Continue Reading

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Citations

Nov 30, 2007·Journal of Virology·Jillian M RojekStefan Kunz
Jan 25, 2013·Viruses·Juan C Zapata, Maria S Salvato
Jun 8, 2012·The Journal of Veterinary Medical Science·Masayuki Shimojima, Yoshihiro Kawaoka
Jan 10, 2008·Cellular Microbiology·Jillian M Rojek, Stefan Kunz
Jan 3, 2013·Cellular Microbiology·Marie-Laurence MorazStefan Kunz
Nov 13, 2007·Virology·Therese ReignierPaula M Cannon
Jun 27, 2006·Virology·Therese ReignierPaula M Cannon
Oct 18, 2005·Advances in Immunology·Francesca GranucciPaola Ricciardi-Castagnoli
Jun 8, 2018·Journal of Virology·Rachel B BrouilletteWendy Maury
Aug 24, 2013·Journal of Virology·Ana-Rita GoncalvesStefan Kunz
Nov 1, 2013·Journal of Virology·Masaharu IwasakiJuan C de la Torre
May 6, 2016·Journal of Virology·Joel OppligerStefan Kunz
Jan 11, 2019·Journal of Virology·Giulia TorrianiStefan Kunz
Apr 26, 2016·Nature Structural & Molecular Biology·Kathryn M HastieErica Ollmann Saphire
Jan 1, 2012·Uirusu·Hideki TaniShigeru Morikawa
Aug 21, 2019·Proceedings of the National Academy of Sciences of the United States of America·Brian C WareMichael B A Oldstone
Feb 23, 2019·Viruses·Tamara Suprunenko, Markus J Hofer
Aug 13, 2020·Viruses·Chiara FedeliStefan Kunz
Mar 28, 2019·MBio·Antonio HerradorStefan Kunz

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