Use of amantadine as substrate for SSAT-1 activity as a reliable clinical diagnostic assay for breast and lung cancer

Future Science OA
Andrew W MaksymiukBram Ramjiawan

Abstract

Spermidine/spermine N1-acetyltransferase (SSAT-1) plays a critical role in cell growth, proliferation and death, and is known to be activated in human cancer cells. Amantadine, a US FDA-approved antiviral drug, is a substrate for SSAT-1 and can be used to indirectly measure SSAT-1 activity because of its conversion to acetylamantadine (AA). This study was undertaken to further validate SSAT-1 activity in breast and lung cancer patients. An increase in the urinary concentration of AA in lung and breast cancer patients was observed. The 0-2 h collection time point was determined to be optimal in revealing significant differences in urinary AA concentration between healthy controls and cancer patients. The high urine concentration of AA could be used as a simple and useful test for the detection of breast and lung cancer.

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Nov 20, 2018·Future Science OA·Andrew W MaksymiukBram Ramjiawan

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Citations

Aug 21, 2019·Future Science OA·Paramjit S TappiaBram Ramjiawan
Apr 6, 2021·Future Science OA·Andrew W MaksymiukDaniel S Sitar
Aug 28, 2021·International Journal of Molecular Sciences·Reem Nooreldeen, Horacio Bach

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Methods Mentioned

BETA
urine collection
acetylation
biopsies
xenograft

Clinical Trials Mentioned

NCT02277938

Software Mentioned

GraphPad Prism
Minitab

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