PMID: 11924551Apr 2, 2002Paper

Use of aminoglutethimide in the treatment of pituitary-dependent hyperadrenocorticism in the dog

The Journal of Small Animal Practice
Alenza M D PérezL Peña

Abstract

The aim of this study was to evaluate the efficacy and safety of aminoglutethimide in the treatment of dogs with pituitary-dependent hyperadrenocorticism (PDH). Ten dogs were diagnosed with PDH based on clinical and laboratory data, adrenal function tests (adrenocorticotropic hormone [ACTH] stimulation test and urinary cortisol/creatinine ratio [UCCR] combined with a high dose oral dexamethasone suppression test) and ultrasonographic evaluation of the adrenal glands. Aminoglutethimide was administered daily at a dose of 15 mg/kg bodyweight for one month. Median basal cortisol concentration and post-ACTH cortisol concentration one month after treatment were significantly lower than pretreatment values. Complete response was achieved in one dog, and partial response was obtained in three dogs. Severe side effects of anorexia, vomiting and weakness occurred in one dog and medication was withdrawn. Two further dogs developed decompensations of concurrent diseases and medication was stopped in these animals as well. Mild toxicity occurred in four dogs. Moderate to severe elevations in liver enzymes occurred in all dogs. The efficacy of this drug is lower than that observed using mitotane and ketoconazole, and adverse effects limit i...Continue Reading

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Citations

Dec 17, 2008·Journal of the American Veterinary Medical Association·Yu-Hsin Lien, Hui-Pi Huang
Apr 15, 2004·Australian Veterinary Journal·J A BraddockA D J Watson
Jan 2, 2004·Veterinary Radiology & Ultrasound : the Official Journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association·Panagiotis MantisReto Neiger

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