Use of aminophylline and enalapril in posttransplant polycythemia

Transplantation
M Mazzali, G A Filho

Abstract

Posttransplant polycythemia (PTP) affects 6-30% of renal transplant recipients and can result in thromboembolic disease. The pathogenesis of PTP remains unknown and may be multifactorial. Although phlebotomy has previously been the treatment for PTP, drugs such as adenosine receptor antagonists or angiotensin-converting enzyme inhibitors can be used to control PTP. The authors performed a prospective study of two different drugs to treat PTP: aminophylline and enalapril. Twenty-seven patients with PTP lasting more than 6 months were evaluated. During phase 1, aminophylline was compared with enalapril. The patients sequentially received aminophylline and enalapril during 12-week periods, intercalated by 12-week periods of no drugs. During phase 2, enalapril was administered for 12 weeks. From January 1984 to December 1993, 110 of 333 patients with PTP lasting more than 6 months (33%) developed polycythemia, and 27 patients were included in the present study. In phase 1, aminophylline had no effect on PTP. Enalapril promoted an erythropoiesis inhibition, characterized by a decrease in hematocrit and an increase in iron stores and ferritin levels. After withdrawal of enalapril, the hematocrit increased and the iron stores decrease...Continue Reading

References

Nov 5, 1977·Lancet·D J ThomasE Zilkha
Dec 15, 1991·Annals of Internal Medicine·R S GastonJ J Curtis
Feb 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D V VlahakosN E Madias
Jun 12, 1982·Lancet·G T Griffing, J C Melby
May 1, 1983·Kidney International·C G WickreW M Bennett
Sep 1, 1980·Archives of Internal Medicine·B R BaconF A Rashad
Sep 1, 1995·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M PerazellaM J Bia
Nov 1, 1994·Kidney International·B A JulianJ J Curtis
Jul 1, 1994·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R S GastonJ J Curtis
Apr 15, 1994·Transplantation·K RellZ Gaciong
Apr 1, 1993·Journal of the American Society of Nephrology : JASN·M A Perazella, M J Bia

❮ Previous
Next ❯

Citations

Jan 5, 2000·Transplantation Proceedings·R JavidG A Rais-Jalali
Mar 13, 2003·Kidney International·Demetrios V VlahakosNicolaos E Madias
Jun 10, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·A K Abu-AlfaM J Bia
Oct 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Sep 6, 2007·The Journal of Clinical Hypertension·Domenic A Sica, Rosemarie Mannino
Jun 22, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Jolanta MalyszkoBruno Watschinger
Dec 29, 2016·Blood·Tiziano BarbuiAlessandra Carobbio
Nov 25, 2020·Clinical Transplantation·Beyann AlzoubiSandesh Parajuli
Jun 25, 2021·World Journal of Transplantation·Beyann AlzoubiSandesh Parajuli
Aug 10, 2021·European Journal of Haematology·Liron HofstetterAnat Gafter-Gvili
Aug 20, 2021·Transplant International : Official Journal of the European Society for Organ Transplantation·Poemlarp MekraksakitWisit Cheungpasitporn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.