PMID: 11606172Oct 19, 2001Paper

Use of an alpha-glucosidase inhibitor to maintain glucose homoeostasis during postprandial exercise in intensively treated Type 1 diabetic subjects

Diabetic Medicine : a Journal of the British Diabetic Association
R Rabasa-LhoretJ L Chiasson

Abstract

We evaluated the effects of an alpha-glucosidase inhibitor, acarbose, on glucose homoeostasis during postprandial exercise in Type 1 diabetic subjects. Seven Type 1 diabetic subjects with good glycaemic control on ultralente-regular insulin were randomized in a single blind cross-over study to acarbose 100 mg or placebo taken with a mixed meal (600 kcal, 75 g carbohydrates), followed 90 min later by 30 min of exercise at 50% maximum aerobic capacity. Glucose turnover was measured by tracer (d-[6,6,2H2]glucose) methodology, and intestinal glucose absorption was quantified using carbohydrate polymers labelled with [13C]glucose. Acarbose resulted in a significant decrease in the postprandial glycaemic rise (mean +/- SEM 2.9 +/- 0.6 vs. 5.0 +/- 0.7 mmol/l; P < 0.005) and in the glycaemic nadir during exercise (- 0.8 +/- 0.6 vs. 0.9 +/- 1.3 mmol/l below baseline; P < 0.05). Total glucose appearance increased similarly under the two treatments during the postprandial (27.0 vs. 27.9 micromol per kg per min) and exercise (33.9 vs. 33.5 micromol per kg per min) periods. Mean glucose absorption was significantly delayed by acarbose (7.8 vs. 10.2 micromol per kg per min; P < 0.02), but was compensated by the lack of postprandial suppressi...Continue Reading

References

Jun 1, 1977·Scandinavian Journal of Clinical and Laboratory Investigation·S MaehlumL Hermansen
Jun 1, 1978·Metabolism: Clinical and Experimental·J RadziukJ Dupre
Dec 1, 1982·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·F PirnayP J Lefebvre
May 1, 1994·International Journal of Sports Medicine·D MassicotteC Hillaire-Marcel
Jan 1, 1994·European Journal of Applied Physiology and Occupational Physiology·J F GautierP J Lefèbvre
Oct 1, 1993·Diabetic Medicine : a Journal of the British Diabetic Association·R Tattersall
Mar 1, 1997·Diabetes Care·P HollanderR F Coniff
Oct 7, 1997·Diabetes Care·R LehmannG A Spinas
Jun 23, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·K S Hershon, P M Hershon
Oct 1, 1956·The American Journal of Physiology·R STEELEN ALTSZULER
Apr 10, 1926·British Medical Journal·R D Lawrence

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Citations

May 8, 2002·Diabetes/metabolism Research and Reviews
Oct 18, 2013·Diabetes Technology & Therapeutics·Satish K GargViral N Shah
Mar 29, 2012·American Journal of Physiology. Endocrinology and Metabolism·A HaidarR Hovorka
Jan 1, 2010·Sports Health·Christine ShugartKarl B Fields
Oct 25, 2007·Pediatric Research·Luisa M RodriguezRubina A Heptulla
Aug 19, 2011·Indian Journal of Endocrinology and Metabolism·Vishvas Garg
Dec 22, 2005·European Journal of Applied Physiology·D MassicotteC Lavoie
Mar 1, 2012·Computer Methods and Programs in Biomedicine·Ahmad HaidarRoman Hovorka
Mar 30, 2010·Nutrition & Metabolism·Sjoerd Aa van den BergKo Willems van Dijk
Sep 21, 2011·Respiratory Physiology & Neurobiology·Julia ToniniRenaud Tamisier
Dec 1, 2007·Obesity Research & Clinical Practice·Shigeharu NumaoKiyoji Tanaka
May 19, 2009·Biochemical Pharmacology·Takatoshi MuraseTadashi Hase
Sep 28, 2004·The American Journal of Clinical Nutrition·Marion Korach-AndréXavier Leverve
Apr 29, 2008·Arquivos brasileiros de endocrinologia e metabologia·Mônica de A Lima Gabbay

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