Use of an Animal Model in Studies of Bacterial Corneal Infection

ILAR Journal
B A CowellS M Fleiszig


Despite medical advancements in available therapies, bacterial corneal infection frequently results in vision loss. Contact lens wear is a common predisposing factor for corneal infection; other reported risk factors are dry eye syndrome, blepharitis, trauma, and surgery. Both the immune defense against infection and the pathogenic mechanisms bacteria employ have been studied in vitro. However, there are complex interactions between the pathogen, the immune system, and the corneal tissue in vivo. Animal models allow the researcher to take the results of in vitro assays and validate their role in corneal infection in a living organism. A murine model is frequently used for studies of the pathogenesis of corneal infection caused by Pseudomonas aeruginosa. In this study, a modified scoring system is introduced that was designed to increase the information derived from this infection model. The new system includes evaluation of area, density, and surface characteristics of the ulceration. Results of in vitro experiments had previously indicated that ExsA, a transcriptional regulator of virulence-associated proteins, was important in pathogenesis of corneal infection caused by P. aeruginosa. Here we use the new scoring system to dem...Continue Reading


Dec 1, 1979·Infection and Immunity·R S BerkL D Hazlett
Nov 1, 1992·Archives of Ophthalmology·P O BuehlerJ Katz
Sep 1, 1991·The Plant Cell·P SterkS C De Vries
Jun 1, 1989·Current Eye Research·R M Franklin
Jul 1, 1988·Antimicrobial Agents and Chemotherapy·J A HobdenJ M Hill
Jan 1, 1987·Antibiotics and Chemotherapy·C S Foster
Mar 1, 1987·The Journal of Clinical Investigation·P M Henson, R B Johnston
Jan 1, 1987·International Ophthalmology Clinics·G Smolin
Nov 1, 1983·Reviews of Infectious Diseases·A S Kreger
May 1, 1984·Infection and Immunity·S J CryzR Germanier
Apr 1, 1983·Proceedings of the Society for Experimental Biology and Medicine·K W BeiselR S Berk
Jan 1, 1995·Methods in Enzymology·L D Hazlett
Sep 1, 1994·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·O CiofuN Høiby
Apr 1, 1994·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·J Parker
May 1, 1993·Current Eye Research·J A HobdenR J O'Callaghan
May 1, 1997·Australian and New Zealand Journal of Ophthalmology·B A CowellR P Schneider
Feb 1, 1971·Infection and Immunity·J R Gerke, M V Magliocco


May 30, 2002·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Michael J Giese, Barry A Weissman
May 23, 2019·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Loretta B Szczotka-FlynnDry Eye Assessment and Management (DREAM) Study Research Group
Dec 15, 2016·Frontiers in Cellular and Infection Microbiology·Beatriz GarcíaLuis M Quirós
Dec 22, 1999·Infection and Immunity·B A CowellS M Fleiszig
Sep 27, 2020·Experimental Eye Research·Irona KhandakerGary Hin-Fai Yam

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