Use of an anionic collagen matrix made from bovine intestinal serosa for in vivo repair of cranial defects

PloS One
Mariane Silva PettianM R Cunha

Abstract

Polymeric biomaterials composed of extracellular matrix components possess osteoconductive capacity that is essential for bone healing. The presence of collagen and the ability to undergo physicochemical modifications render these materials a suitable alternative in bone regenerative therapies. The objective of this study was to evaluate the osteogenic capacity of collagen-based matrices (native and anionic after alkaline hydrolysis) made from bovine intestinal serosa (MBIS). Twenty-five animals underwent surgery to create a cranial defect to be filled with native and anionic collagen matrixes, mmineralized and non mineralized. The animals were killed painlessly 6 weeks after surgery and samples of the wound area were submitted to routine histology and morphometric analysis. In the surgical area there was new bone formation projecting from the margins to the center of the defect. More marked bone neoformation occurred in the anionic matrices groups in such a way that permitted union of the opposite margins of the bone defect. The newly formed bone matrix exhibited good optical density of type I collagen fibers. Immunoexpression of osteocalcin by osteocytes was observed in the newly formed bone. Morphometric analysis showed a gr...Continue Reading

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Citations

Aug 30, 2019·Lasers in Medical Science·Daniel Alves Dos SantosMarcelo Rodrigues Cunha
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Fernando Bento CunhaMarcelo Rodrigues da Cunha

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Methods Mentioned

BETA
X-ray
xenograft
chemical modification

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