PMID: 9187427Jan 1, 1997Paper

Use of an anti-ALK antibody in the characterization of anaplastic large-cell lymphoma of childhood

Annals of Oncology : Official Journal of the European Society for Medical Oncology
R E HutchisonS W Morris

Abstract

Anaplastic lymphoma kinase (ALK) is a tyrosine kinase inappropriately expressed in lymphoid tissue involved by CD30+ anaplastic large-cell lymphoma (ALCL) with the translocation t(2;5)(p23;q35)(, which juxtaposes the nucleophosmin gene (NPM) with that encoding ALK, resulting in a hybrid (NPM-ALK) message. A polyclonal antibody against residues of the kinase portion of NPM-ALK (designated anti-ALK 11) was tested for clinical utility in paraffin sections of 44 cases of pediatric large-cell lymphoma (LCL) and 17 additional lymphoma cases, by streptavidin-biotin-alkaline phosphatase method. Nineteen of 20 CD30+ cases (the majority exhibiting anaplastic morphology) labeled with anti-ALK 11, and 5/28 CD30- cases were also ALK+ (3 T cells, 1 null cell, and 1 B cell). Sixteen of 17 B-cell pediatric LCLs were negative, as were 6/6 cases of Hodgkin's disease and 7/7 cases of adult B-cell lymphoma. In pediatric LCLs with adequate follow-up (24/44 ALK+), there was no significant association between ALK expression and two-year event-free survival, similar to the finding reported previously for CD30 expression in these cases. We conclude that the majority of pediatric CD30+ ALCLs show ALK overexpression, consistent with the presence of the t...Continue Reading

Citations

Jul 28, 2010·Current Hematologic Malignancy Reports·Fatma V Okur, Robert Krance
Mar 16, 2002·Journal of Clinical Pathology·S A PileriH Stein
Aug 31, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffery L Kutok, Jon C Aster
Mar 29, 2002·Cancer·Angela J AlessandriBonnie G Massing
Nov 16, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Larisa V DebelenkoJulia A Bridge
Jun 14, 2001·British Journal of Haematology·S W MorrisM C Kinney
Sep 21, 2001·British Journal of Haematology·B Falini

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