Use of an enzyme-linked immunosorbent assay technique in the differential diagnosis of active pulmonary tuberculosis in humans

The Journal of Infectious Diseases
S B KalishE Metzger

Abstract

Sera from patients with active pulmonary tuberculosis and pulmonary diseases frequently mimicking tuberculosis were assayed for immunoglobulin G antibody activity to purified protein derivative (PPD) by an enzyme-linked immunosorbent assay. A method of standardization was developed to limit assay variation. Patients with active pulmonary tuberculosis had a significantly greater mean level of antibody than had patients with atypical tuberculosis (P = 0.005), sarcoidosis (P = 0.0001), histoplasmosis (P = 0.004), blastomycosis (P = 0.008), or cryptococcosis (P = 0.017), patients who had received bacille Calmette-Guérin vaccination (P = 0.003) or who had a history of treated tuberculosis (P = 0.003), and PPD skin test-positive and skin test-negative control subjects (P = 0.001). This technique may have potential use as a rapid diagnostic aid in evaluating patients with suspected active pulmonary tuberculosis.

Citations

Sep 1, 1990·Indian Journal of Pediatrics·N M Wagle, A K Vaidya
Sep 1, 1990·Indian Journal of Pediatrics·P Maniar, L Joshi
Dec 15, 1990·Lancet·T S van der WerfS Yong
Feb 1, 1993·Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology·C SavageH Leclerc
Dec 1, 1986·The Journal of Hygiene·F L Garcia-CarreñoR Hernandez
Feb 1, 1994·International Journal of Dermatology·V N SehgalK Logani
Feb 1, 1990·Zentralblatt für Veterinärmedizin. Reihe B. Journal of veterinary medicine. Series B·V RitaccoI N de Kantor
Oct 24, 2003·Infection and Immunity·Rakesh Kumar ChoudharySeyed E Hasnain
Jul 1, 1986·Journal of Clinical Pathology·E KrambovitisD T Hughes
Jun 22, 2012·Veterinary Medicine International·Ashutosh WadhwaShigetoshi Eda
Apr 1, 1991·The American Review of Respiratory Disease·B A Steele, T M Daniel
Apr 19, 2008·Tropical Medicine & International Health : TM & IH·Blanca I RestrepoJaime Robledo
Sep 5, 2001·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A YüceE S Uçan
May 10, 2001·Scandinavian Journal of Infectious Diseases·T A TessemaB Bjorvatn
Jul 1, 1986·Journal of Clinical Microbiology·S R CoatesD F Echenberg
Dec 1, 1990·Journal of Clinical Microbiology·A A WadeeS G Reddy
May 1, 1986·Journal of Clinical Microbiology·M A YáñezH Yeager
Apr 2, 2003·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·E KunterS Cavuslu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.