Jun 1, 1984

Use of an intravenous sodium load in screening for primary hyperaldosteronism

Australian and New Zealand Journal of Medicine
G S StokesB A Mennie


A sodium loading test was performed in 35 patients presenting with hypertension and hypokalemia. In 14 of these patients, intravenous administration of 0.9% saline (2 l in 4 h) on two consecutive days caused urinary aldosterone excretion to fall to values within the range for normal volunteers. The other 21 patients, in whom urinary aldosterone excretion did not decline following two days of saline loading, or in whom pronounced hypokalemia after the first day of loading precluded further saline infusion, were designated as having primary aldosteronism. Seventeen of this group underwent surgery and discrete adrenal adenomas were found in 16. When serum potassium concentration, plasma renin activity or the relationships of serum potassium to concurrent urinary potassium excretion or of urinary aldosterone excretion to plasma renin activity were used as alternative diagnostic criteria for primary aldosteronism, overlapping of the two groups occurred. It is concluded that measurement of urinary aldosterone excretion after intravenous sodium loading is a useful test in the test in the identification of primary aldosteronism due to aldosterone-producing adenoma. In this series the saline loading test was more specific in diagnosis t...Continue Reading

  • References22
  • Citations6


  • References22
  • Citations6


Mentioned in this Paper

Aldosterone Measurement
Serum Potassium Measurement
Aldosterone Urine
Conn Syndrome
Body Excretions
Diuretic Effect
Hypertensive Disease

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