PMID: 15348221Sep 7, 2004Paper

Use of an osteoinductive biomaterial as a bone morphogenetic protein carrier

Journal of Materials Science. Materials in Medicine
H YuanK de Groot

Abstract

A porous calcium phosphate ceramic, which induced bone formation in soft tissues of dogs, was termed as osteoinductive biomaterial and studied as a carrier of bone morphogenetic protein (rhBMP-2). Cylinder implants (laser spot 4 x 5 mm) impregnated with 0, 1, 10 and 40 microg rhBMP-2 were implanted in dorsal muscles of rabbits for five weeks. Histological observation and histomorphometric analysis were performed on thin un-decalcified sections. No bone formation was detected in the implants without rhBMP-2, while mature lamellar bone was found inside the implants with 1 microg rhBMP-2, both on the outer surface and inside the implants with 10 microg and 40 microg rhBMP-2. Little difference in formed bone was found between 1 microg and 10 microg rhBMP-2, but no difference was found between 10 microg and 40 microg rhBMP-2. A significant difference in bone marrow formation was found among 1, 10 and 40 microg rhBMP-2. The more rhBMP-2, the more bone marrow formed. The present results indicate that osteoinductive biomaterial is a good carrier of BMP and high dose of BMP is not necessary for bone formation in clinic.

Citations

Apr 3, 2008·Journal of Tissue Engineering and Regenerative Medicine·P C BessaR L Reis
Jan 5, 2014·Clinical Orthopaedics and Related Research·Frank G LyonsFergal J O'Brien
Dec 9, 2010·Journal of Materials Science. Materials in Medicine·X ZhangX D Zhang
Jun 15, 2013·Journal of Biomedical Materials Research. Part a·Venkata P MantripragadaAmbalangodage C Jayasuriya
Mar 17, 2015·Journal of Materials Science. Materials in Medicine·Adel M F AlhalawaniMark R Towler
Sep 13, 2019·Clinical Oral Implants Research·Javier Sanz-EsporrinMariano Sanz
Jul 8, 2009·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hélène AutefageChristian Rey
Oct 2, 2008·Tissue Engineering. Part B, Reviews·Johan BeneschRui L Reis
Oct 18, 2016·Journal of Biomedical Materials Research. Part a·Ganggang ZhangMarthe Rousseau
May 22, 2008·Tissue Engineering. Part a·Ander AbarrategiJosé Luís López-Lacomba
May 23, 2015·Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission·F Özdal-KurtS I Deliloğlu-Gürhan
Mar 21, 2009·Journal of Biomedical Materials Research. Part a·Jérôme SohierPierre Layrolle
Nov 27, 2007·Journal of Tissue Engineering and Regenerative Medicine·Pamela Habibovic, Klaas de Groot

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