Use of analogues and the substrate-sensitivity of mutants in analysis of purine uptake and breakdown in Aspergillus nidulans.

Journal of Bacteriology
A J Darlington, C Scazzocchio

Abstract

Aspergillus mutants resistant to various purine analogues (purine, 8-azaguanine, 2-thioxanthine, and 2-thiouric acid) are defective in at least one step of purine uptake or breakdown. The properties of these mutants show that there are two uptake systems for purines, one which mediates the uptake of hypoxanthine, guanine, and adenine, and the other, xanthine and uric acid. Allantoinase-less strains are sensitive to the toxic effects of allantoin accumulation. They are severely inhibited when grown in the presence of naturally occurring purines. Mutant strains derived from these, resistant to naturally occurring purines, may be isolated. These are either wild-type revertants, or carry a second metabolic block in the uptake or breakdown of purines. The properties of these double mutants confirm the interpretation of the nature of the analogue-resistant mutants.

Citations

Feb 21, 1975·European Journal of Biochemistry·C Bailey, H N Arst
Sep 16, 2000·Molecular Membrane Biology·H de Koning, G Diallinas
Aug 5, 2003·Functional & Integrative Genomics·Matthew M TanzerJeffrey R Shuster
Dec 17, 2009·Molecular Microbiology·Christos GournasGeorge Diallinas
Oct 14, 2014·Fungal biology and biotechnology·Claudio Scazzocchio
May 9, 1973·Molecular & General Genetics : MGG·H N Arst, D W MacDonald
Nov 2, 1973·Molecular & General Genetics : MGG·H N Arst, D J Cove
Nov 5, 2003·The Journal of Biological Chemistry·Gianna CecchettoChristine Drevet
Feb 26, 2015·Molecular Microbiology·Emilia KrypotouGeorge Diallinas
Feb 13, 2016·Microbiology and Molecular Biology Reviews : MMBR·Monika SchmollAlfredo Herrera-Estrella
Sep 6, 2007·FEMS Microbiology Reviews·Areti Pantazopoulou, George Diallinas
Dec 22, 1976·Molecular & General Genetics : MGG·T F Tsao, G A Marzluf
Aug 5, 1975·Molecular & General Genetics : MGG·W R Reinert, G A Marzluf
Aug 13, 2005·Molecular Membrane Biology·Sophia GoudelaGeorge Diallinas
Sep 1, 1979·Journal of Toxicology and Environmental Health·R BenigniV A Ortali
May 9, 2018·International Journal of Molecular Sciences·Christos GournasVicky Sophianopoulou
Feb 1, 1968·Journal of Bacteriology·J H Thakar, G P Kalle
Jul 1, 1969·Journal of Bacteriology·M V ElorzaC Scazzocchio
Sep 24, 1968·Biochimica Et Biophysica Acta·C Scazzocchio, A J Darlington
Jun 1, 1969·Journal of Bacteriology·H N Arst, D J Cove
Dec 1, 1977·Mutation Research·M BignamiG Morpurgo
Oct 1, 1975·Journal of Bacteriology·J M Magill, C W Magill
Dec 4, 2003·Fungal Genetics and Biology : FG & B·Javier Valdez-TaubasAlberto L Rosa
Feb 9, 2006·Journal of Molecular Biology·Anna VlantiGeorge Diallinas

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