Abstract
To assess factors associated with early or delayed androgen deprivation therapy (ADT) among men diagnosed with metastatic prostate cancer, and to assess the relationship between ADT and overall survival, as there is uncertainty about the ideal timing for initiating ADT in men with metastatic prostate cancer. We studied a population-based cohort of American men aged >or=66 years diagnosed with metastatic prostate cancer during 1992-2002 and followed to 2003. We assessed the receipt of ADT early (<or=4 months from diagnosis), delayed (>4 months), or not at all, using multinomial logistic regression to identify factors associated with treatment, and Cox proportional-hazard models to assess whether treatment was associated with survival. Overall, 69.5% of men received early ADT and 7.3% delayed. Adjusted rates of early ADT were lower for black than white men (58.3% vs 71.0%), and of delayed ADT were higher for black than white men (12.7% vs 6.2%). Receipt of ADT was associated with improved survival (adjusted hazard ratio 0.69, 95% confidence interval 0.66-0.73). The benefit of early treatment did not differ from delayed treatment (P = 0.58). A large minority of men with metastatic prostate cancer, particularly black men, receive d...Continue Reading
References
Apr 1, 1991·American Journal of Epidemiology·K E RaglandD W Merrill
Jan 1, 1990·Quality Assurance in Health Care : the Official Journal of the International Society for Quality Assurance in Health Care·J E Wennberg
Jan 1, 1987·Journal of Chronic Diseases·M E CharlsonC R MacKenzie
Aug 1, 1993·Medical Care·A L PotoskyL G Kessler
Apr 15, 1993·Cancer·P N BrawnN F Bell
Feb 1, 1997·British Journal of Urology
Jul 1, 1997·The Journal of Urology·J E FowlerM D Dabagia
Sep 28, 1998·Medical Care·C N KlabundeB S Kramer
May 1, 1999·Urology·M C HallC G Roehrborn
Dec 22, 1999·The Journal of Urology·J E FowlerN K Kilambi
Mar 7, 2002·Journal of the National Cancer Institute·Vickie L Shavers, Martin L Brown
Jul 3, 2003·Journal of the National Cancer Institute·Matthew R CooperbergPeter R Carroll
Sep 27, 2003·Social Science & Medicine·Theodore J Iwashyna, Nicholas A Christakis
Nov 5, 2003·Health Services Research·Arlene S AshLindsey Bramwell
Jun 9, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D Andrew LoblawUNKNOWN American Society of Clinical Oncology
Dec 15, 2004·Urology·Steven B ZeliadtDavid F Penson
Mar 3, 2005·Cancer·Vahakn B ShahinianJames S Goodwin
Jul 15, 2005·JAMA : the Journal of the American Medical Association·Nima SharifiWilliam L Dahut
Dec 31, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy L KeatingJohn Z Ayanian
Feb 14, 2006·Cancer·Xianglin L DuWenyaw Chan
Mar 4, 2006·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Jul 4, 2006·The Journal of Urology·Grace Lu-YaoSiu-Long Yao
Jul 25, 2006·Medical Care·Laura-Mae BaldwinGeorge Wright
Aug 2, 2006·BJU International·Michael J BarryDavid C Wennberg
Sep 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy L KeatingMatthew R Smith
Jan 16, 2007·The Journal of Urology·Grace Lu-YaoSiu-Long Yao
Apr 4, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D Andrew LoblawUNKNOWN American Society of Clinical Oncology
Citations
Mar 15, 2011·Acta Pharmacologica Sinica·Yu-hsiang LinKe-hung Tsui
Dec 7, 2010·Journal of the National Cancer Institute·Sean P ElliottBeth A Virnig
May 8, 2013·Actas urologicas españolas·M Ramírez-BackhausE Solsona
Apr 25, 2009·BJU International·Christopher J DiBlasioIthaar H Derweesh
Apr 17, 2016·World Journal of Urology·Alex Z FuArnold L Potosky
Mar 19, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Arnold L PotoskyStephen K Van Den Eeden
Jul 13, 2018·BMC Cancer·Laura OrtelliAndrea Bordoni
Sep 6, 2017·BJU International·Dennis R TaaffeDaniel A Galvão
Jul 1, 2018·Journal of Racial and Ethnic Health Disparities·Chi NguyenXianglin L Du
Jul 1, 2018·Cancer Causes & Control : CCC·Marie C BradleyArnold L Potosky
Mar 29, 2011·Urology·Eberechukwu OnukwughaArif Hussain
Apr 25, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity