PMID: 8948002Nov 1, 1996Paper

Use of animal models in peptic ulcer disease

Psychosomatic Medicine
H Weiner

Abstract

Considerable progress has been made in the understanding of the formation of gastric erosions by the use of animals. The role of gastric acid secretion in their pathogenesis has been clarified. Gastric erosions are associated with the presence of acid in the stomach and slow gastric contractions. With several different experimental procedures, the animal's body temperature falls; preventing the fall averts erosions. A fall in body temperature or exposure to cold are associated with the secretion of thyrotropin-releasing hormone (TRH), and both increased and decreased concentration of corticotropin-releasing factor (CRH) in discrete regions of rat brains. Thyrotropin-releasing hormone when injected into specific sites in the brain produces gastric erosions and increases acid secretion and slow contractions, whereas CRH has the opposite effects. One of the major sites of interaction of the two peptides is in the dorsal motor complex of the vagus nerve. Thyrotropin-releasing hormone increases serotonin (5-HT) secretion into the stomach. Serotonin counter-regulates acid secretion and slow contractions. Many other peptides injected into discrete brain sites stimulate or inhibit gastric acid secretion.

References

Aug 1, 1978·Japanese Journal of Pharmacology·S YanoM Harada
Mar 1, 1976·Journal of Comparative and Physiological Psychology·J M WeissM Gruenthal
Mar 1, 1975·Psychosomatic Medicine·S H AckermanH Weiner
Jan 1, 1991·Epidemiologic Reviews·D N Taylor, M J Blaser
Oct 17, 1991·The New England Journal of Medicine·A NomuraM J Blaser
Jan 1, 1990·Annals of the New York Academy of Sciences·M TanakaH Nishimura
Feb 14, 1991·Biochemical and Biophysical Research Communications·A RobertY Taché
Jul 1, 1991·The Medical Clinics of North America·H R Mertz, J H Walsh
Jan 1, 1990·Annals of the New York Academy of Sciences·D E Hernandez
Jan 1, 1990·Annals of the New York Academy of Sciences·R L StephensY Taché
Jan 1, 1990·Annals of the New York Academy of Sciences·C V Grijalva, D Novin
Mar 29, 1990·The New England Journal of Medicine·A H Soll
Jan 1, 1990·Annals of the New York Academy of Sciences·Y Taché, H Yang
Jan 1, 1990·Gastroenterology·B RybergH Mattsson
Feb 1, 1990·Gastroenterology·C Fiocchi, J H Finke
Jan 1, 1990·Annals of the New York Academy of Sciences·A Tsuda, M Tanaka
Jan 1, 1990·Annals of the New York Academy of Sciences·W P Paré
Jul 15, 1985·Life Sciences·A CowanD E Gmerek
Mar 1, 1989·Journal of the Autonomic Nervous System·M J McCannR C Rogers
Aug 1, 1989·Gastroenterology·G Flemström, G Jedstedt
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H J Lenz

❮ Previous
Next ❯

Citations

Oct 22, 2005·Digestive Diseases and Sciences·George M Strain, Ron D Waldrop
Jun 13, 2012·Nitric Oxide : Biology and Chemistry·Mohamed A MorsyRemon R Rofaeil
Jan 24, 2009·Journal of Ethnopharmacology·Clélia Akiko Hiruma-LimaAlba Regina Monteiro Souza Brito
Feb 8, 2011·Phytotherapy Research : PTR·Endale MeleseEphrem Engidawork
Feb 16, 2006·Autonomic Neuroscience : Basic & Clinical·J Bruce OvermierAnne-Marita Milde
Apr 5, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·A Lee
Nov 1, 1996·Psychosomatic Medicine·M A Hofer
Dec 29, 2018·Journal of Dairy Science·J D BusL E Webb
Dec 1, 2010·Molecular and Cellular Biochemistry·S I ChandranathJ Singh
Jun 5, 1998·The American Journal of Physiology·K MiyataS Fukudo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.