Use of animal studies in risk assessment for immunotoxicology

M I LusterD R Germolec


We have previously reported on the design and content of a screening battery involving a 'tier' approach for detecting potential immunosuppressive compounds in mice. This battery has been used to examine a variety of compounds, and the database generated from these studies, which consists of over 50 compounds, has been collected and analyzed in an attempt to improve the accuracy and efficiency of screening chemicals for immunosuppression and to identify better those tests that predict experimentally-induced, immune-mediated diseases. Specifically, these analyses attempted to develop an improved testing configuration for the accurate prediction of immunotoxic agents and to provide insight into the qualitative and quantitative relationships between a number of immune and host resistance assays commonly employed to examine potential immunotoxic chemicals in experimental animals. While a number of limitations existed in the analyses, several conclusions were drawn from the results which will be discussed.


Jan 1, 1992·Critical Reviews in Food Science and Nutrition·D M Hinton
Feb 11, 1992·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M I LusterG J Rosenthal
Oct 1, 1990·Toxicology Letters·R M Pillai, R R Watson
Jan 1, 1987·Teratogenesis, Carcinogenesis, and Mutagenesis·G L KimmelE Z Francis
Jan 1, 1988·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·M I LusterJ H Dean
Mar 1, 1988·Risk Analysis : an Official Publication of the Society for Risk Analysis·C A Kimmel, D W Gaylor
Jan 1, 1982·Immunological Reviews·J L Turk, D Parker


Aug 1, 1996·International Journal of Immunopharmacology·E J de WaalH Van Loveren
Mar 14, 2001·Toxicology·L D Koller
Mar 18, 2000·Toxicology Letters·J T ZelikoffM Anderson
Dec 1, 1995·Environmental Health Perspectives·K KrzystyniakM Fournier
Dec 6, 2000·Immunopharmacology and Immunotoxicology·D B ColagiovanniG M Shopp
Jan 6, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·S W Burchiel, M I Luster
Feb 24, 2001·Inhalation Toxicology·M H Karol, D Stoliker
Oct 14, 2020·Nature Immunology·Takafumi SuzukiMasayuki Yamamoto

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