Use of anti-epileptic drugs in a tertiary care hospital of Eastern India with emphasis on epilepsy due to neurocysticercosis.

Indian Journal of Pharmacology
Amrita SilSantanu K Tripathi

Abstract

Epilepsy is a chronic disease and neurocysticercosis is an important cause of secondary seizures. Its therapy is modified by a number of parameters and thus the pattern of anti-epileptic drugs used varies in different clinical settings. It was our objective to evaluate clinico-demographic and treatment profile of epilepsy patients attending neurology outpatient department, efficacy and side-effect profile of anti-epileptic drugs with special emphasis on epilepsy resulting from neurocysticercosis. This was a cross-sectional descriptive study of epilepsy patients over four months in neurology outpatient department. Clinico-biological data were obtained by interrogating patients and from recorded data using standard case-report form. 79 patients were studied with 54.43% having primary etiology, 40.51% having seizures secondary to neurocysticercosis. 81% had generalized tonic-clonic seizure, 17.7% partial and 1.3% myoclonic seizures. Phenytoin (86.08%), valproate (30.38%), clobazam (26.58%) and carbamazepine (10.13%) were used either alone or in combination, with no use of anthelmintics even in cases of neurocysticercosis. Control of seizure was obtained in 79.7% with significant decrease in seizure frequency from 2.92 to 0.51 (P <...Continue Reading

References

May 1, 1989·Radiology·L D KramerJ Daryabagi
Sep 13, 1984·The New England Journal of Medicine·M P Grodofsky, R W Wilmott
Oct 1, 1996·Journal of the Neurological Sciences·O H Del BruttoP M Schantz
Jul 1, 1999·Epilepsia·R Sridharan, B N Murthy
May 11, 2000·Journal of Child Neurology·P SinghiN Khandelwal
Jun 5, 2003·Acta Tropica·Héctor H García, Oscar H Del Brutto
Oct 30, 2007·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Kamalesh DasOm Prakash Singh
Feb 22, 2011·British Journal of Clinical Pharmacology·Hector H GarciaUNKNOWN Cysticercosis Working Group in Peru
Apr 27, 2011·Developmental Medicine and Child Neurology·Pratibha Singhi

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Citations

Jan 5, 2013·Neurology India·Akanksha N ThakkarUrmila M Thatte
Sep 16, 2014·Annals of Indian Academy of Neurology·George KoshyThomas Vizhalil Paul
Feb 15, 2013·Therapeutic Drug Monitoring·Santosh R TaurUrmila M Thatte

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Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.

Anthelmintics

Anthelmintics or antihelminthics are a group of antiparasitic drugs that expel parasitic worms (helminths) and other internal parasites from the body by either stunning or killing them and without causing significant damage to the host. Discover the latest research on anthelmintics here.