Use of antibiotic disks to evolve drug-resistant bacteria

Antonie van Leeuwenhoek
J Nicole Flanagan, Todd R Steck

Abstract

The methods used to generate antibiotic-resistant bacterial strains can be labour-intensive, costly, lengthy and/or prone to plate-to-plate variation. We propose a simple, inexpensive and easily replicated method to expose bacteria to a continuous gradient of antibiotic concentration, providing an environment of positive selective pressure for evolution of antibiotic-resistant strains.

References

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Citations

Aug 9, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Jerilyn Nicole FlanaganTodd R Steck

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