Use of antibiotics in patients who were attacked by animals that can transmit rabies v1

Jorge Machado Alba


Introduction:Animal bites have a high probability of becoming infected. In high-risk wounds, the use of antibiotics that kill the associated microorganisms is recommended. Objective: To determine the use of antibiotics in patients in different regions of Colombia who were attacked in 2020 by animals that can transmit rabies. Materials and methods: This was a retrospective follow-up study of a cohort of patients with wounds caused by animals; the patients were affiliated with the Colombian Health System. Sociodemographic, clinical and pharmacological data were collected. Results: A total of 280 patients were analyzed. The median age was 28.0 years, and 52.1% were men. The attacks were attributed to dogs (85.0%) and cats (15.0%), and 9.6% were classified as severe exposure. Antibiotics were used in 71.1% of cases for prophylaxis and in 4.3% of the cases for the treatment of superinfection; cephalexin (37.5%), amoxicillin/clavulanic acid (15.7%) and dicloxacillin (10.4%) were the predominant antibiotics used. A total of 72.0% of patients who received antibiotics received inadequate prescriptions, and 49.2% had no indication to receive prophylaxis. Being treated in the Caribbean region (OR:4.09; 95%CI:1.79-9.30) and receiving analg...Continue Reading

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