Use of antidepressant medications in relation to the incidence of breast cancer

British Journal of Cancer
D Fulton-KehoeN S Weiss

Abstract

Although associations have been reported between antidepressant use and risk of breast cancer, the findings have been inconsistent. We conducted a population-based case-control study among women enrolled in Group Health Cooperative (GHC), a health maintenance organization in Washington State. Women with a first primary breast cancer diagnosed between 1990 and 2001 were identified (N = 2904) and five controls were selected for each case (N = 14396). Information on antidepressant use was ascertained through the GHC pharmacy database and on breast cancer risk factors and screening mammograms from GHC records. Prior to one year before diagnosis of breast cancer, about 20% of cases and controls had used tricyclic antidepressants (adjusted odds ratio = 1.06, 95% CI 0.94-1.19) and 6% of each group had used selective serotonin reuptake inhibitors (OR = 0.98, 95% CI 0.80-1.18). There also were no differences between cases and controls with regard to the number of prescriptions filled or the timing of use. Taken as a whole, the results from this and other studies to date do not indicate an altered risk of breast cancer associated with the use of antidepressants overall, by class, or for individual antidepressants.

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Citations

Dec 7, 2007·Breast Cancer Research and Treatment·Jessica ChubakNoel S Weiss
Oct 3, 2006·Expert Review of Neurotherapeutics·Patricia F Coogan
Jan 21, 2018·Breast Cancer Research : BCR·John BusbyChris R Cardwell
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Jul 20, 2007·Breast Cancer Research and Treatment·Patricia F CooganLynn Rosenberg
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Aug 4, 2007·Breast Cancer Research and Treatment·M ReichC Perdrizet-Chevallier
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Feb 6, 2018·The Open Orthopaedics Journal·Josette Bettany-SaltikovRichard Webb
Jan 30, 2015·Journal of Autism and Developmental Disorders·Tineke Backer van OmmerenSander Begeer
Mar 8, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Agnès FournierFrançoise Clavel-Chapelon
Nov 10, 2012·Breast Cancer Research and Treatment·Chun-Sick EomKyung-Hwan Cho
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Nov 19, 2015·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Susan B BrownKatherine W Reeves

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