Use of antidepressant serotoninergic medications and cardiac valvulopathy: a nested case-control study in the health improvement network (THIN) database.

British Journal of Clinical Pharmacology
Francesco LapiAnnalisa Rubino

Abstract

To quantify the risk of cardiac valvulopathy (CV) associated with the use of antidepressant serotoninergic medications (SMs). We conducted a case-control study nested in a cohort of users of antidepressant SMs selected from The Health Improvement Network database. Patients who experienced a CV event during follow-up were cases. Cases were ascertained in a random sample of them. Up to 10 controls were matched to each case by sex, age, month and year of the study entry. Use of antidepressant SMs during follow-up was defined as current (the last prescription for antidepressant SMs occurred in the 2 months before the CV event), recent (in the 2-12 months before the CV event) and past (>12 months before the CV event). We fitted a conditional regression model to estimate the association between use of antidepressant SMs and the risk of CV by means of odds ratios (ORs) and corresponding 95% confidence intervals (CIs). Sensitivity analyses were conducted to test the robustness of our results. The study cohort included 752,945 subjects aged 18-89 years. Throughout follow-up, 1663 cases (incidence rate: 3.4 per 10,000 person-years) of CV were detected and were matched to 16,566 controls. The adjusted OR (95% CI) for current and recent us...Continue Reading

References

Apr 18, 2001·The American Journal of Cardiology·S T MastJ G Jollis
Jun 27, 2002·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·F E LotrichR E Ferrell
Mar 15, 2003·The New England Journal of Medicine·Jacob E MøllerPatricia A Pellikka
Mar 23, 2005·Circulation·Björn I GustafssonHelge Waldum
Jul 8, 2005·Psychosomatics·Mark D Williams, Tamara J Dolenc
Oct 28, 2005·The New England Journal of Medicine·J John Mann
Oct 27, 2006·Pharmacoepidemiology and Drug Safety·James D LewisBrian L Strom
Jan 5, 2007·The New England Journal of Medicine·Bryan L Roth
Jan 5, 2007·The New England Journal of Medicine·René SchadeEdeltraut Garbe
Jan 5, 2007·The New England Journal of Medicine·Renzo ZanettiniGianni Pezzoli
Dec 19, 2008·American Journal of Therapeutics·Richard B Rothman, Michael H Baumann
Jan 27, 2009·Movement Disorders : Official Journal of the Movement Disorder Society·Frank Andersohn, Edeltraut Garbe
Jan 31, 2009·Journal of the American College of Cardiology·Avinoam Shiran, Alex Sagie
May 16, 2009·Nature Reviews. Endocrinology·Maralyn DruceAshley B Grossman
Jun 10, 2009·Expert Opinion on Drug Safety·Richard B Rothman, Michael H Baumann
Jun 26, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Sakima A SmithVictor G Davila-Roman
Jul 15, 2009·European Journal of Clinical Pharmacology·Simona MonteGianni Tognoni
Feb 4, 2010·QJM : Monthly Journal of the Association of Physicians·M R DruceA B Grossman
Jan 26, 2011·Nature Reviews. Cardiology·Bernard Iung, Alec Vahanian

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Citations

Mar 5, 2015·Expert Opinion on Drug Metabolism & Toxicology·Janet SultanaGianluca Trifirò
Nov 28, 2014·Journal of Clinical Pharmacology·Franco LapiSamy Suissa
Mar 29, 2018·Clinical Drug Investigation·Annalisa BiffiUNKNOWN Italian Group for Appropriate Drug prescription in the Elderly (I-GrADE)
May 7, 2020·Expert Opinion on Drug Safety·Diana BrasseletBénédicte Lebrun-Vignes

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