Use of antidepressants during pregnancy and neonatal outcomes: An umbrella review of meta-analyses of observational studies

Journal of Psychiatric Research
Annalisa BiffiGiovanni Corrao

Abstract

Pregnant women who suffer from depressive disorders are likely to be treated with antidepressant (AD) medications. Recent meta-analyses underlined the possible relation between AD use and several neonatal outcomes, although the underlying mechanisms remains unclear. To summarise and evaluate the associations between AD use in pregnancy and neonatal outcomes, we conducted an umbrella review of meta-analyses of observational studies published up to December 2019 in PubMed and Embase. Summary risk estimates for the associations between use of AD as a whole, or specific AD classes and drugs, and the risk of neonatal outcomes were reported. Our review included 22 meta-analyses investigating 69 associations. However, none were supported by convincing evidence. Highly suggestive evidence regarded the associations between (i) any time AD exposure and the risk of preterm birth (relative risk, 1.68; 95% confidence interval 1.52, 1.86), (ii) any time exposure to selective serotonin reuptake inhibitors (SSRIs) and the risk of preterm birth (1.43; 1.22, 1.37) and (iii) respiratory distress (1.33; 1.14, 1.55), and (iv) SSRI exposure during the first trimester of pregnancy and the risk of cardiovascular malformations (1.25; 1.13, 1.39). Sugge...Continue Reading

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Citations

Dec 29, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Georgios SchoretsanitisOlav Spigset
Dec 12, 2020·Journal of Obstetrics and Gynaecology Canada : JOGC = Journal D'obstétrique Et Gynécologie Du Canada : JOGC·Alison K SheaKellie E Murphy
Nov 3, 2021·JAMA : the Journal of the American Medical Association·Hilary K Brown, Simone N Vigod

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