Use of antihypertension agents for the suppression of arterial pulse pressure waveforms in patients with intracranial aneurysms

Journal of Neurosurgery
Carole L TurnerPeter J Kirkpatrick

Abstract

Patients with intracranial aneurysms tend toward raised blood pressure and abnormal pulse pressure profiles. The authors have investigated the influence of three antihypertension agents on blood pressure and pulse pressure waveforms in patients with known intracranial aneurysms, with a view to assessing the potential benefits of longterm antihypertension therapy on the progression of unruptured intracranial aneurysms. Nineteen patients with a mean age of 56 years (range 38-76 years) were recruited for this study. All patients had confirmed intracranial aneurysms. A double-blind, randomized, crossover study was performed using perindopril, irbesartan, isosorbide mononitrate, and a placebo. Blood pressure and pulse pressure waveforms were assessed at the end of each 4-week treatment period. Perindopril and irbesartan were well tolerated. For all measured parameters except heart rate (p = 0.03), no significant difference between baseline and placebo was identified. Each drug when compared with placebo reduced peripheral arterial blood pressure. Perindopril significantly decreased mean blood pressure by 10 mm Hg (p = 0.004), irbesartan by 9 mm Hg (p = 0.004), and isosorbide mononitrate by 13 mm Hg (p = 0.005). The administration of...Continue Reading

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Citations

Nov 9, 2010·Journal of Neurosurgery·Erin N KiehnaAaron S Dumont
Jul 19, 2018·International Journal of Stroke : Official Journal of the International Stroke Society·Mervyn DI VergouwenNima Etminan

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