PMID: 4901345Nov 29, 1969Paper

Use of antilymphocyte globulin after cadaveric renal transplantation

British Medical Journal
P B DoakJ D North

Abstract

Antilymphocyte globulin (A.L.G.) was prepared by injecting fresh frozen splenic cells subcutaneously into horses. The IgG fraction of the serum was concentrated by a batch technique using diethylaminoethanol-Sephadex. Fourteen patients given this material by intramuscular injection after cadaveric renal transplants, in addition to azathioprine and prednisone, had less evidence of rejection compared with patients previously treated with azathioprine and prednisone only, despite a reduction of the mean daily prednisone dose from 65 to 45 mg. Toxicity, especially local reaction, fever, and hypotension, limited the amount of A.L.G. that was given.

Citations

May 20, 1971·The New England Journal of Medicine·J A MannickD C Nabseth
Feb 1, 1979·Irish Journal of Medical Science·E C Sweeney, L McDonnell
Apr 1, 1973·The American Journal of Medicine·R J AndersonT C Eickhoff
Jun 17, 2020·Transplantation·Song C Ong, Robert S Gaston

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