Use of Antimalarial Agents is Associated with Favourable Physical Functioning in Patients with Systemic Lupus Erythematosus

Journal of Clinical Medicine
Alvaro GomezIoannis Parodis

Abstract

Impaired health-related quality of life (HRQoL) is a major problem in patients with systemic lupus erythematosus (SLE). Antimalarial agents (AMA) are the cornerstone of SLE therapy, but data on their impact on HRQoL are scarce. We investigated this impact using baseline data from the BLISS-52 (NCT00424476) and BLISS-76 (NCT00410384) trials (n = 1684). HRQoL was self-reported using the Medical Outcomes Study short-form 36 (SF-36), functional assessment of chronic illness therapy (FACIT)-Fatigue and 3-level EuroQoL 5-Dimension (EQ-5D) questionnaires. Patients on AMA (n = 1098/1684) performed better with regard to SF-36 physical component summary, physical functioning, role physical, bodily pain, FACIT-Fatigue, EQ-5D utility index and EQ-5D visual analogue scale scores. The difference in SF-36 physical functioning (mean ± standard deviation (SD): 61.1 ± 24.9 versus 55.0 ± 26.5; p < 0.001) exceeded the minimal clinically important difference (≥5.0). This association remained significant after adjustment for potential confounding factors in linear regression models (standardised coefficient, β = 0.07; p = 0.002). Greater proportions of AMA users than non-users reported no problems in the mobility, self-care, usual activities and anx...Continue Reading

References

Dec 22, 2000·Spine·J E Ware
Dec 16, 2005·The New England Journal of Medicine·Michelle PetriUNKNOWN OC-SELENA Trial
Feb 28, 2007·Annals of the Rheumatic Diseases·Nathalie Costedoat-ChalumeauJean-Charles Piette
Jun 1, 2005·Expert Review of Pharmacoeconomics & Outcomes Research·Vibeke Strand, Bruce Crawford
Aug 27, 2010·Journal of the American Academy of Dermatology·Annegret KuhnGisela Bonsmann
Oct 20, 2011·Nature Reviews. Nephrology·Senq-J LeeJoanne M Bargman
Mar 15, 2014·Expert Review of Pharmacoeconomics & Outcomes Research·Silvia CorettiPaul McNamee
Jul 4, 2015·Medical Decision Making : an International Journal of the Society for Medical Decision Making·Eleanor M PullenayegumFeng Xie
Jun 17, 2016·Nature Reviews. Disease Primers·Arvind KaulGraham Hughes
Jan 23, 2019·Patient Related Outcome Measures·Elvira BangertZahi Touma
Mar 31, 2019·Annals of the Rheumatic Diseases·Antonis FanouriakisDimitrios T Boumpas

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Software Mentioned

AMA
SPSS
GraphPad Prism

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

Arizona Medicine
R B Roth
Virginia Medical Monthly
L H BAUER
The Journal of the Kentucky Medical Association
D B Stevens
© 2022 Meta ULC. All rights reserved