PMID: 11450176Jul 14, 2001

Use of antipsychotic drugs and lithium in mania

The British Journal of Psychiatry. Supplement
John C Cookson


Studies highlighting the difficulties associated with lithium suggest that the role of antipsychotic drugs and mood stabilizers in bipolar disorder should be reconsidered. To review the efficacy and mode of action of antipsychotic drugs in mania, and to consider the differences between official guidelines and routine clinical practice in the use of these agents for mania. Review of research, guideline- and practice-based literature. Guidelines recommend lithium or valproate as first-line treatments for mania, and antipsychotic agents only as 'adjuncts' for agitation, dangerous behaviour or psychosis. However, in routine practice, antipsychotic drugs are often prescribed. The effectiveness of these agents in mania has been established by several studies; newer atypical compounds demonstrate antimanic efficacy with a reduced incidence of neurological side-effects. Antipsychotic drugs are important in the treatment of bipolar disorder and mania. Future studies should evaluate the long-term efficacy and safety of newer atypical antipsychotic agents, and the place of anticonvulsants in combination with antipsychotics in bipolar disorder.


Nov 13, 1976·Lancet·J B Loudon, H Waring
Jul 1, 1979·The American Journal of Psychiatry·A P West, H Y Meltzer
Sep 1, 1979·The American Journal of Psychiatry·G M AsnisR R Fieve
Aug 1, 1978·The American Journal of Psychiatry·R M PostF K Goodwin
Sep 1, 1976·Archives of General Psychiatry·J M HimmelhochD J Kupfer
Oct 1, 1976·The American Journal of Psychiatry·R H GernerW E Bunney
Dec 11, 1992·The American Journal of Psychiatry·S L McElroyA C Swann
Feb 1, 1991·Journal of Clinical Psychopharmacology·J C Chou
Jan 1, 1991·International Clinical Psychopharmacology·N Hunt, T Silverstone
May 1, 1991·The American Journal of the Medical Sciences·L D Ziegler, A U Buzdar
Feb 1, 1990·Journal of Clinical Psychopharmacology·G S SachsL Jones
Nov 30, 1989·The New England Journal of Medicine·A J GelenbergJ Lavelle
Apr 1, 1986·Archives of General Psychiatry·S MukherjeeS Shukla
Aug 1, 1987·Psychological Medicine·A J Wood, G Goodwin
Apr 1, 1989·Archives of General Psychiatry·R M PostR Cowdry
Dec 1, 1986·Biological Psychiatry·G Chouinard, W Steiner
May 1, 1985·Journal of Affective Disorders·J Cookson
Jan 1, 1988·Journal of Personality Assessment·L S Mullins, R E Kopelman
Jun 30, 1988·The New England Journal of Medicine·A LaupacisR S Roberts
May 1, 1985·The British Journal of Psychiatry : the Journal of Mental Science·J CooksonG M Besser
Nov 1, 1974·Archives of General Psychiatry·D L Murphy, A Beigel
Dec 2, 1974·JAMA : the Journal of the American Medical Association·W J Cohen, N H Cohen
Feb 1, 1974·Archives of General Psychiatry·D L Dunner, R R Fieve
Jan 1, 1967·Archives of General Psychiatry·D F Klein
Jul 1, 1980·Pharmakopsychiatrie, Neuro-Psychopharmakologie·A KukopulosL Tondo
Mar 1, 1983·Archives of General Psychiatry·B J HamraR Finn
Jan 1, 1984·Schizophrenia Bulletin·P J Goodnick, H Y Meltzer
Oct 27, 1984·British Medical Journal·T H TurnerG M Besser
Dec 1, 1980·Journal of Affective Disorders·P E GarfinkelE Persad
Dec 1, 1984·Acta Psychiatrica Scandinavica·M SCHOU
Jan 1, 1981·Neuropsychobiology·W M VerhoevenJ T de Jong
Feb 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·P TyrerI Lee
Aug 1, 1980·The American Journal of Psychiatry·J M HimmelhochS M Licata
Jul 1, 1995·The American Journal of Psychiatry·R J BaldessariniF Centorrino
Dec 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·R LittlejohnJ Cookson
Jan 1, 1994·The American Journal of Psychiatry·M J SernyakS W Woods
Jul 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·A RifkinR Munne
Apr 1, 1993·Journal of Affective Disorders·H Verdoux, M Bourgeois
Jan 1, 1993·International Clinical Psychopharmacology·E WhiteT Silverstone
May 1, 1997·The Journal of Clinical Psychiatry·M J SernyakS W Woods
May 1, 1997·Journal of Psychosomatic Research·A N SinghJ Catalan
Mar 1, 1997·International Clinical Psychopharmacology·J C SoaresS Gershon
Mar 1, 1997·International Clinical Psychopharmacology·B BarbiniE Smeraldi
Oct 23, 1997·Journal of the American Academy of Child and Adolescent Psychiatry·A RaineS A Mednick
Aug 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·J Moncrieff
Aug 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·John C Cookson
Mar 21, 1998·The Journal of Clinical Psychiatry·H Y LaneW H Chang
Jul 21, 1998·Acta Psychiatrica Scandinavica·R W Licht
Jul 22, 1998·The Journal of Clinical Psychiatry·J P Lindenmayer, R Klebanov
Dec 24, 1998·Journal of Clinical Psychopharmacology·R I Shader, D J Greenblatt
Mar 13, 1999·The Journal of Clinical Psychiatry·M S BauerB J Powell
Sep 4, 1999·Journal of Psychopharmacology·D Zullino, P Baumann
Jul 14, 2001·The British Journal of Psychiatry. Supplement·J R CalabreseS E Kimmel
Nov 1, 1954·Journal of Neurology, Neurosurgery, and Psychiatry·M SCHOUH VOLDBY
Jan 1, 1995·Journal of Psychopharmacology·H J ScurlockJ Catalan


Feb 3, 2005·Social Psychiatry and Psychiatric Epidemiology·Evelyn J BrometQing Ye
Jun 26, 2003·Brain Research. Molecular Brain Research·Zhi-Hao ZhangQiang Wang
May 22, 2002·Journal of Ethnopharmacology·John D ConnorEyasu Makonnen
Nov 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Nikhil M UrsMarc G Caron
Aug 4, 2004·International Clinical Psychopharmacology·Dimitris SamellasJohn C Cookson
Feb 1, 2004·Acta Neuropsychiatrica·M T Abou-Saleh
Oct 20, 2012·PloS One·Liam MasonWael El-Deredy
Feb 12, 2014·L'Encéphale·Pierre Alexis GeoffroyChantal Henry
Mar 7, 2003·The Journal of ECT·Fernando Madalena Volpe, Almir Tavares
Apr 19, 2005·Acta Psychiatrica Scandinavica. Supplementum·S M Carney, G Goodwin
Oct 19, 2007·Acta Psychiatrica Scandinavica. Supplementum·G S Sachs, E E Gardner-Schuster
Oct 26, 2012·CNS Neuroscience & Therapeutics·Pierre Alexis GeoffroyFrank Bellivier
Oct 29, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Chi-Un PaeIn-Ho Paik
Feb 21, 2006·European Psychiatry : the Journal of the Association of European Psychiatrists·R M JonesI Bitter
Mar 15, 2015·Nordic Journal of Psychiatry·Alfredo Carlo AltamuraMassimiliano Buoli
Sep 12, 2015·The Lancet. Psychiatry·Abebaw FekaduMartin J Prince
Mar 31, 2009·Journal of Psychopharmacology·G Goodwin, Consensus Group of the British Association for Psychopharmacology
Jul 23, 2003·Journal of Psychopharmacology·G Goodwin, Consensus Group of the British Association for Psychopharmacology
Jan 22, 2003·The Cochrane Database of Systematic Reviews·K MacritchieG Goodwin

Related Concepts

Manic Disorder
Nervous System Disorder
Antipsychotic Effect
Best Practices
Lithium Compounds
Selection of Subjects
Antimanic Effect

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