PMID: 7537489May 1, 1995Paper

Use of aprotinin in LVAD recipients reduces blood loss, blood use, and perioperative mortality

The Annals of Thoracic Surgery
D J GoldsteinM C Oz

Abstract

Aprotinin, a bovine protease inhibitor, has been used extensively in patients undergoing cardiac surgical procedures in an effort to minimize blood loss and prevent the complications associated with blood replacement. We sought to evaluate the effect of aprotinin on postoperative blood loss, renal function, and the incidence of right ventricular failure in patients undergoing placement of a TCI Heartmate left ventricular assist device as a bridge to cardiac transplantation. Retrospective data analysis in 142 patients (42 receiving aprotinin and 100 untreated) demonstrated that the use of aprotinin was associated with a significant decrease in postoperative blood loss (p = 0.019) and in the intraoperative packed red blood cell transfusion (p = 0.019) and total blood product (p = 0.016) requirements. A transient, yet significant, increase in the postoperative creatinine level in the aprotinin group (p = 0.0006), but not in blood urea nitrogen level (p = 0.22), was noted. Interestingly, we noted an association between blood loss and the subsequent development of right ventricular failure; patients who required a right ventricular assist device bled significantly more than did those who did not suffer right ventricular failure (p =...Continue Reading

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Citations

Mar 1, 2009·Journal of Cardiovascular Translational Research·Ranjit John, Sangjin Lee
Feb 1, 1996·The Annals of Thoracic Surgery·D J GoldsteinE Delphin
Sep 1, 1996·The Annals of Thoracic Surgery·T W PrendergastV Jeevanandam
Sep 4, 1999·The Annals of Thoracic Surgery·D MavroidisW E Pae
Jun 1, 2002·Journal of the American College of Cardiology·Michael P SiegenthalerFriedhelm Beyersdorf
Feb 1, 1997·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S J RooneyR S Bonser
Oct 26, 2002·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Carmelo A MilanoMark Stafford Smith
Mar 14, 2003·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Paul L DiGiorgiMehmet C Oz
Apr 8, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·J C StringhamS V Karwande
Oct 4, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·P M McCarthy, N G Smedira
Oct 4, 2000·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·W Piccione
Nov 20, 1998·The New England Journal of Medicine·D J GoldsteinE A Rose
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Jan 29, 2003·Heart Disease·Sheldon Goldstein, David Amar
Apr 22, 2008·Artificial Organs·Rajko RadovancevicO Howard Frazier
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May 30, 2013·Indian Journal of Anaesthesia·Hiriyur Shivalingappa JayanthkumarKanchi Muralidhar
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Aug 28, 2007·The Annals of Thoracic Surgery·Jacob N SchroderCarmelo A Milano
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May 1, 1998·The Annals of Thoracic Surgery·D Royston
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Jul 19, 2015·Nitric Oxide : Biology and Chemistry·Maria BenedettoNandor Marczin
Nov 6, 2008·Expert Opinion on Drug Safety·Marie Bosman, David Royston
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