Use of assumed versus measured oxygen consumption for the determination of cardiac output using the Fick principle

Catheterization and Cardiovascular Diagnosis
A WolfE L Alderman

Abstract

Assumed oxygen consumption (VO2) is increasingly used as a convenient surrogate for measured VO2 for calculation of cardiac output. This substitution is often based on empirical formulae, previously validated only in relatively young patients. To assess the inaccuracy introduced by extrapolating these formulae to older patients, we compared measured VO2 with assumed VO2 in 57 patients. VO2 was measured using an open circuit analyzer. Assumed VO2 was calculated according to the LaFarge or Bergstra formulae. Agreement between both methods was assessed according to the method of Bland and Altman. The mean difference of measured VO2 minus assumed VO2 was 7.9 ml/min/m2 (P < 0.02) using the LaFarge formula, and -15.6 ml/min/m2 (P < 0.0002) using the Bergstra formula across a range of measured VO2 from 70 to 176 ml/min/m2. A systematic error was introduced by assumed VO2 from both formulae of underestimating higher and overestimating lower values of VO2, resulting in poor overall agreement with measured VO2. The same error and poor agreement was found when analyzing subgroups of patients > or =60 or <70 years of age. In summary, use of assumed VO2 introduces large, unpredictable errors in adult patients, suggesting requirement for mea...Continue Reading

References

Mar 1, 1988·European Heart Journal·A H KendrickA Rozkovec
Nov 1, 1985·Journal of Applied Physiology·W Perez, M J Tobin
Jan 1, 1970·Cardiovascular Research·C G LaFarge, O S Miettinen
Aug 1, 1982·Clinical Cardiology·G J DehmerL D Hillis
Apr 1, 1963·American Heart Journal·H SANDLERC E RACKLEY
May 10, 1952·Lancet·J D ROBERTSON, D D REID

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Citations

Nov 22, 2011·The American Journal of Cardiology·Nikhil NarangDarren K McGuire
Mar 25, 2009·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·François HaddadDavid Rosenthal
Mar 16, 2016·Cardiovascular Revascularization Medicine : Including Molecular Interventions·Zaher FanariAndrew J Doorey
Apr 11, 2012·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Jia Li
May 25, 2013·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Zachary M GertzHoward C Herrmann
Nov 10, 2010·Seminars in Cardiothoracic and Vascular Anesthesia·Jacob Pugsley, Adam B Lerner
Mar 11, 2015·Circulation·Anton Vonk NoordegraafPaul M Hassoun
Oct 1, 2013·Circulation·Nikhil NarangDarren K McGuire
Jun 1, 2012·Circulation. Cardiovascular Interventions·Zachary M GertzHoward C Herrmann
Jan 8, 2019·Clinical Cardiology·Wilson C KwanDavid R Laughrun
Sep 10, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Sameer J KhandharCatalin Toma
Jun 24, 2003·AACN Clinical Issues·Jan M Headley
Nov 30, 2021·Pneumologie·Ralf EwertChristian F Opitz

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