Use of autologous instead of allogeneic blood transfusion during esophagectomy prolongs disease-free survival among patients with recurrent esophageal cancer

Journal of Surgical Oncology
Satoru MotoyamaJun-Ichi Ogawa

Abstract

A substantial body of evidence suggests that allogeneic blood transfusion increases the rate of recurrence of resected malignancies. The present study was conducted with the aim of understanding better the clinical characteristics of recurrent esophageal cancer and determining whether any survival advantage is conferred by transfusing autologous instead of allogeneic blood during the esophagectomy for the original malignancy. We retrospectively analyzed 123 patients who received blood transfusion while undergoing esophagectomy for thoracic esophageal cancer between January 1991 and February 1998. We focused on those patients in whom the malignancy recurred. Of them, 23 patients received allogeneic blood and 18 received autologous blood. Compared were the clinico-pathological factors influencing prognosis as well as the disease-free survival periods and the period of survival after recurrence of the cancer. The clinico-pathological factors that influenced prognosis were similar in the two groups. There was also no significant difference in the rate at which the esophageal cancer recurred, or in survival time once it had recurred. On the other hand, disease-free survival prior to recurrence was significantly prolonged in the auto...Continue Reading

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Citations

Jan 20, 2009·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Frederike C LingPaul M Schneider
Oct 13, 2011·World Journal of Gastroenterology : WJG·Yoshito TomimaruHiroaki Nagano
Apr 3, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S SugitaS Kitano
May 16, 2006·Thoracic Surgery Clinics·Ryan C Fields, Bryan F Meyers
Oct 7, 2015·Journal of Surgical Oncology·Yasmin Abu-GhanemJacob Ramon
Jan 21, 2015·Clinical Genitourinary Cancer·Ayman SoubraBadrinath R Konety
Dec 22, 2017·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·P R BoshierG B Hanna
Jan 19, 2010·British Journal of Hospital Medicine·Irene Bouras, Olivia Mingo

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