Use of Autologous Serum Tears for the Treatment of Ocular Surface Disease From Patients With Systemic Autoimmune Diseases

American Journal of Ophthalmology
Tayyeba K AliVictor L Perez

Abstract

To describe the safety and efficacy of autologous serum tears (AST) in managing ocular surface disease resistant to conventional therapy in patients with systemic autoimmune disease(s). Retrospective, interventional case series. Records of patients from 2009 to 2015 with systemic autoimmune disease treated with AST (20%-50%) for chronic surface disease were analyzed. Standardized measures of subjective dry eye symptoms, objective dry eye staining of the cornea, and slit-lamp findings including punctate epithelial erosion (PEE), filamentary keratopathy (FK), and corneal epithelial defects (KED) were compared during first and last visit. We attempted to standardize outcomes by creating a scale from 1 to 4 for subjective and objective components: worsening (1), no improvement (2), partial improvement (3), and complete resolution (4). Fifty-one patients (101 eyes) were included. The mean age was 59.8 ± 13.2 years (72.5% female). Average use of AST was 14.3 ± 11.7 months. Complete objective improvement of initial slit-lamp findings was achieved in 30% and partial improvement in 55% of eyes. Presence of PEE, FK, and KED decreased from 92.1% to 52.5% (P < .001), from 22.8% to 9.9% (P = .02), and from 5% to 2% (P = .44) of the eyes, re...Continue Reading

Citations

Jan 25, 2019·Blood·Stefanie SarantopoulosKeith M Sullivan
Nov 26, 2019·Leukemia & Lymphoma·Saurabh ChhabraMehdi Hamadani
Feb 29, 2020·Ophthalmology and Therapy·Giuseppe GiannaccareVincenzo Scorcia
Dec 31, 2020·International Journal of Molecular Sciences·M Elizabeth FiniMark R Wilson
Oct 13, 2020·Experimental Eye Research·Sneh PatelAnat Galor

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