Use of beta-blockers and risk of fractures

JAMA : the Journal of the American Medical Association
Raymond G SchliengerChristoph R Meier

Abstract

Animal studies suggest that the beta-blocker propranolol increases bone formation, but data on whether use of beta-blockers (with or without concomitant use of thiazide diuretics) is associated with reduced fracture risk in humans are limited. To determine whether use of beta-blockers alone or in combination with thiazides is associated with a decreased risk of fracture in adults. Case-control analysis using the UK General Practice Research Database (GPRD). The study included 30,601 case patients aged 30 to 79 years with an incident fracture diagnosis between 1993 and 1999 and 120,819 controls, matched to cases on age, sex, calendar time, and general practice attended. Odds ratios (ORs) of having a fracture in association with use of beta-blockers or a combination of beta-blockers with thiazides. The most frequent fractures were of the hand/lower arm (n = 12,837 [42.0%]) and of the foot (n = 4627 [15.1%]). Compared with patients who did not use either beta-blockers or thiazide diuretics, the OR for current use of beta-blockers only (> or =3 prescriptions) was 0.77 (95% confidence interval [CI], 0.72-0.83); for current use of thiazides only (> or =3 prescriptions), 0.80 (95% CI, 0.74-0.86); and for combined current use of beta-b...Continue Reading

Citations

Apr 18, 2014·Clinical Interventions in Aging·Kamil Serkan AğaçayakSerhat Atılgan
Jan 9, 2014·Pharmacological Reports : PR·Leszek SliwińskiHenryk I Trzeciak
Sep 13, 2012·European Journal of Endocrinology·G MazziottiA Giustina
Oct 12, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·K A ToulisJ P Bilezikian
Sep 10, 2013·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D XingY Chen
Feb 20, 2007·Calcified Tissue International·F de VriesT P van Staa
Aug 12, 2014·Calcified Tissue International·Tzu-Cheng LeeYoungho Seo
Nov 15, 2011·Annual Review of Physiology·Gerard Karsenty, Franck Oury
Aug 17, 2014·Journal of General Internal Medicine·Karen L MargolisAnn V Schwartz
Sep 18, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F J A Penning-van BeestR M C Herings
Nov 7, 2009·European Heart Journal·Laura CarboneJohn R Robbins
Jan 19, 2013·World Journal of Orthopedics·Patrizia D'AmelioGiovanni Carlo Isaia
Oct 10, 2012·Nature Reviews. Rheumatology·Douglas J DiGirolamoStavroula Kousteni
May 4, 2006·Clinical Rheumatology·Jorge Morales-Torres
Mar 1, 2013·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Kentaro HanamiYoshiya Tanaka
Jul 23, 2011·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Hironori NakagamiRyuichi Morishita
Apr 19, 2007·Calcified Tissue International·M S Patel, F Elefteriou
Nov 30, 2012·Calcified Tissue International·Katarina IlićNada Vujasinović-Stupar
Aug 11, 2011·American Journal of Nephrology·Shunsuke GotoMasafumi Fukagawa
Mar 3, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·C MeisingerA Döring
Oct 10, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M W Hamrick, S L Ferrari
Apr 22, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S M OttK Wu
Jul 14, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S D BerryY Zhang
Jun 30, 2012·Journal of Bone and Mineral Metabolism·Ya-Feng ZhangTimothy C Y Kwok
May 10, 2011·Medicinski pregled·Vesna V Radović
Feb 1, 2007·The American Journal of Chinese Medicine·Wenping ZhangTorao Ishida
Nov 6, 2008·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·F Andersohn, E Garbe
Feb 2, 2006·European Journal of Clinical Pharmacology·Stefan Viktor VormfeldeJürgen Brockmöller
Feb 13, 2007·Hormone Research·Juan Carlos Martín-EscuderoJavier Mena Martín
Aug 13, 2008·Expert Opinion on Investigational Drugs·Simon GrahamEleftherios Tsiridis
Apr 19, 2005·Expert Opinion on Investigational Drugs·Andrew Grey, Ian R Reid
Jul 16, 2010·Expert Opinion on Investigational Drugs·Ritu TrivediNaibedya Chattopadhyay
Sep 19, 2007·Expert Opinion on Emerging Drugs·Andrew Grey
Sep 14, 2006·Current Medical Research and Opinion·C H A van den BoogaardR M C Herings
Oct 17, 2008·Current Medical Research and Opinion·Willemijn M MeijerRon M C Herings
Jan 27, 2007·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Bahi TakkoucheMahyar Etminan
Jul 14, 2009·The American Journal of the Medical Sciences·Syed H RazaLaura D Carbone
Feb 24, 2015·International Journal of Cardiology·Hyung Jin ChoiChan Soo Shin
Sep 27, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Matthew Daniel Morrison, Faleh Tamimi

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