PMID: 16515763Mar 7, 2006Paper

Use of biochemical markers to study and follow patients with osteoarthritis

Current Rheumatology Reports
P Garnero

Abstract

Osteoarthritis is characterized by progressive destruction of articular cartilage and subchondral bone and synovial reaction. Radiologic findings that form the basis of the diagnosis of osteoarthritis are poorly sensitive to detect early disease and for monitoring progression of joint damage. Blood-based proteomic analyses suggest that biochemical alterations can be observed well before radiologic damage is evidenced. New cartilage-specific markers, including assays for type II collagen synthesis and degradation, have been developed. Recent prospective studies indicate that blood and urine levels of these new markers are associated with progression of joint damage. Biological markers respond rapidly to treatment and therefore will certainly play an important role in the development and the monitoring of disease-modifying therapies. Because osteoarthritis involves different tissues and complex biologic processes, a combination of different biochemical markers appears to be the most promising diagnostic strategy.

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Citations

Apr 21, 2010·Knee Surgery, Sports Traumatology, Arthroscopy : Official Journal of the ESSKA·Ida Carøe HelmarkM Kjaer
Sep 1, 2009·Assay and Drug Development Technologies·Anne-Christine Bay-JensenPer Qvist
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Jun 13, 2009·Arthritis Research & Therapy·Steven B Abramson, Mukundan Attur
Apr 18, 2007·Current Rheumatology Reports·Nadine Charni-Ben Tabassi, Patrick Garnero
Jan 24, 2012·Best Practice & Research. Clinical Rheumatology·Per QvistMorten A Karsdal
May 6, 2008·Best Practice & Research. Clinical Rheumatology·Johanne Martel-PelletierPeter J Roughley
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Jan 21, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Per QvistAnne-Christine Bay-Jensen

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