Use of bioinformatic analyses in identifying characteristic genes and mechanisms active in the progression of idiopathic thrombocytopenic purpura in individuals with different phenotypes.

The Journal of International Medical Research
Mengyi Zhang, Binhan Guo

Abstract

To explore the mechanism underlying the progression of newly diagnosed idiopathic thrombocytopenic purpura (ITP) to its chronic or remission state using bioinformatic methods. GSE56232 and GSE46922 gene expression profile datasets were downloaded from Gene Expression Omnibus (GEO). Differentially expressed genes were identified and characteristic genes were screened by weighted gene co-expression network analysis. These genes were used for function enrichment analysis and construction of a protein-protein interaction network. Finally, characteristic genes were verified to determine potential molecular mechanisms underlying ITP progression. We found that characteristic genes in the chronic ITP group were mainly involved in intracellular processes and ion binding, while characteristic genes in the remission ITP group were involved in intracellular processes and nuclear physiological activities. We identified a sub-network of characteristic genes, LMNA, JUN, PRKACG, SMC3, which may indicate the mechanism by which newly diagnosed ITP progresses to chronic. Although no meaningful signaling pathways were found, the expression of NR3C1, TPR, SMC4, PANBP2, CHD1, and U2SURP may affect ITP progression from newly diagnosed to remission. O...Continue Reading

References

Jan 12, 2008·World Journal of Gastroenterology : WJG·Praveen K RoyJamal A Ibdah
Dec 17, 2008·Journal of Thrombosis and Haemostasis : JTH·B H Chong
Dec 31, 2008·BMC Bioinformatics·Peter Langfelder, Steve Horvath
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Oct 16, 2009·Annual Review of Immunology·Tomohiro KurosakiYoshihiro Baba
Nov 19, 2010·British Journal of Haematology·Lisa J Toltl, Donald M Arnold
Oct 18, 2012·Journal of Pediatric Hematology/oncology·John A D'OrazioNina Farhoudi
Dec 4, 2012·Nucleic Acids Research·Andrea FranceschiniLars J Jensen
Aug 8, 2013·Expert Opinion on Biological Therapy·Alan H Lazarus
Oct 18, 2013·Frontiers in Immunology·Kelley M FracchiaCraig M Walsh
Sep 10, 2014·Current Protocols in Bioinformatics·Gang SuGary D Bader
Jan 22, 2015·Nucleic Acids Research·Matthew E RitchieGordon K Smyth
Feb 5, 2016·Thrombosis and Haemostasis·Margareta JernåsBob Olsson
Jan 23, 2017·Methods in Enzymology·G PeiW Zhang
Feb 18, 2017·Journal of Clinical Medicine·Anne ZuffereyJohn W Semple
Feb 7, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Cheng QianAnmei Deng
Apr 4, 2018·Clinical Diabetes and Endocrinology·Melis SahinozElif A Oral
Mar 15, 2019·Hämostaseologie·Rahil Kohli, Shruti Chaturvedi
Aug 28, 2019·Dermatology : International Journal for Clinical and Investigative Dermatology·Xianglan LiMingji Zhu
Nov 15, 2019·The International Journal of Neuroscience·Mohsen MoradiMaryam Rezazadeh
Dec 4, 2019·Blood Advances·Cindy NeunertSara K Vesely
Jan 14, 2020·Indian Journal of Pediatrics·Gurpreet SinghNicola A M Wright
Feb 6, 2020·Gene·Muhammad Tarek AbdelGhafarHanem Rabah
Sep 2, 2020·International Immunopharmacology·Morteza Mousavi-HasanzadehAziz Eghbali

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE56232
GSE46922

Software Mentioned

limma
Search Tool for the Retrieval
Cytoscape
R package
WGCNA
DAVID
STRING
R
Cytohubba
R package “ WGCNA ”

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Hematology
S Ozsoylu
Pediatric Hematology and Oncology
S Ozsoylu
© 2021 Meta ULC. All rights reserved