PMID: 9555542Apr 29, 1998Paper

Use of biological response modifiers in the treatment of cutaneous T-cell lymphoma

Current Opinion in Oncology
A H RookZ Niu

Abstract

Cutaneous T-cell lymphoma (CTCL) is typically a skin-infiltrating, clonal proliferative disorder of CD4+ T cells that exhibit a T-helper type 2 cytokine phenotype. Therapeutic decisions are based on the extent of disease and the observations that host-antitumor responses occur and that these responses may be blunted by the immunosuppressive cytokines produced by the malignant T cells. Biologic response modifiers, which may enhance cell-mediated immunity and antitumor responses, are active agents in the treatment of CTCL. The rationale and use of biologic response modifiers to treat CTCL are reviewed in this article.

Citations

Aug 24, 2007·The Journal of Investigative Dermatology·Jessica S YoonAlain H Rook
Jan 19, 2007·Clinical Lymphoma & Myeloma·Stephen K RichardsonAlain H Rook
Aug 25, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·C C VittorioJ M Junkins-Hopkins

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