Use of biologics during pregnancy and risk of serious infections in the mother and baby: a Canadian population-based cohort study

BMJ Open
Nicole W TsaoMary A De Vera

Abstract

To investigate the association between exposure to biologics during pregnancy and serious infections in mothers and infants. Retrospective cohort study. Population-based. Women with one or more autoimmune diseases identified by International Classification of Diseases 9th/10th revision codes in healthcare administrative databases in British Columbia, Canada, who had pregnancies ending in a live or stillbirth between 1 January 2002 and 31 December 2012. Women were defined as exposed if they had at least one biologic prescription during pregnancy, and infants born to these women were considered exposed in utero. Disease-matched women with no biologics prescriptions during pregnancy, and their infants, comprised the unexposed groups. Serious infections requiring hospitalisation. Over the 10-year study period, there were 6218 women (8607 pregnancies) who had an autoimmune disease diagnosis, of which 90 women were exposed to biologics during pregnancy, with 100 babies born to these women. Among women exposed to biologics during pregnancy, occurrence of serious postpartum infections were low, ranging from 0% to 5%, depending on concomitant exposures to immunosuppressants. In multivariable models using logistic regression, the OR for ...Continue Reading

Citations

Jul 27, 2020·Alimentary Pharmacology & Therapeutics·Gabriella BrömsFredrik Granath
Dec 31, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Ting-Yun YeLi-Fei Zhu

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Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

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